微小外显子作用重大。
Microexons go big.
机构信息
Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology; CAS Center for Excellence in Brain Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; School of Life Science and Technology, ShanghaiTech University, Shanghai, 200031, China.
出版信息
Cell. 2014 Dec 18;159(7):1488-9. doi: 10.1016/j.cell.2014.12.004.
Microexons are frequently underestimated in transcriptome analyses. Two studies published in Cell and Genome Research now independently report the identification of hundreds of microexons. Alternative splicing of some microexons is regulated by neuronal-specific RNA-binding proteins and modifies the function of proteins involved in neurogenesis, with misregulation linked to autism.
微外显子在转录组分析中经常被低估。现在有两项发表在《细胞》和《基因组研究》上的研究独立报告了数百个微外显子的鉴定。一些微外显子的可变剪接受神经元特异性 RNA 结合蛋白调控，并改变参与神经发生的蛋白质的功能，其调控失常与自闭症有关。
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