钯催化通过双C(sp(2))-H键活化形成芳基-芳基键：[3,4]-稠合氧化吲哚的高效合成
Pd-catalyzed dehydrogenative aryl-aryl bond formation via double C(sp(2))-H bond activation: efficient synthesis of [3,4]-fused oxindoles.
作者信息
Bunescu Ala, Piou Tiffany, Wang Qian, Zhu Jieping
机构信息
Laboratory of Synthesis and Natural Products, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, EPFL-SB-ISIC-LSPN , BCH 5304, 1015 Lausanne, Switzerland.
出版信息
Org Lett. 2015 Jan 16;17(2):334-7. doi: 10.1021/ol503442n. Epub 2014 Dec 19.
PMID:25525910
Abstract
A Pd(0)-catalyzed double cyclization of easily available o-bromoanilides leading to strained [3,4]-fused oxindoles was developed. The reaction proceeded through a highly ordered sequence involving key carbopalladation, 1,4-Pd migration, and C(sp(2))-H functionalization steps.
摘要
开发了一种钯（0）催化的易于获得的邻溴苯甲酰胺的双环化反应，该反应可生成具有张力的[3,4]稠合氧化吲哚。该反应通过一个高度有序的序列进行，该序列涉及关键的碳钯化、1,4-钯迁移和C(sp(2))-H官能团化步骤。
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