Boase Natasha Anne, Kumar Sharad
Centre for Cancer Biology, University of South Australia, Adelaide, SA 5001, Australia.
Centre for Cancer Biology, University of South Australia, Adelaide, SA 5001, Australia.
Gene. 2015 Feb 25;557(2):113-22. doi: 10.1016/j.gene.2014.12.020. Epub 2014 Dec 17.
Ubiquitination plays a crucial role in regulating proteins post-translationally. The focus of this review is on NEDD4, the founding member of the NEDD4 family of ubiquitin ligases that is evolutionarily conserved in eukaryotes. Many potential substrates of NEDD4 have been identified and NEDD4 has been shown to play a critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumour suppressor PTEN. In this review we will discuss the diverse pathways in which NEDD4 is involved, and the patho-physiological significance of this important ubiquitin ligase.
泛素化在蛋白质翻译后调控中发挥着关键作用。本综述的重点是NEDD4，它是泛素连接酶NEDD4家族的创始成员，在真核生物中具有进化保守性。已鉴定出许多NEDD4的潜在底物，并且NEDD4已被证明在多种膜受体、内吞机制组件和肿瘤抑制因子PTEN的调控中发挥关键作用。在本综述中，我们将讨论NEDD4所涉及的多种途径，以及这种重要泛素连接酶的病理生理意义。
