Burnstock Geoffrey, Pelleg Amir
Autonomic Neuroscience Centre, University College Medical School, Rowland Hill Street, London, NW3 2PF, UK,
Purinergic Signal. 2015 Mar;11(1):1-46. doi: 10.1007/s11302-014-9436-1. Epub 2014 Dec 20.
This review is a historical account about purinergic signalling in the heart, for readers to see how ideas and understanding have changed as new experimental results were published. Initially, the focus is on the nervous control of the heart by ATP as a cotransmitter in sympathetic, parasympathetic, and sensory nerves, as well as in intracardiac neurons. Control of the heart by centers in the brain and vagal cardiovascular reflexes involving purines are also discussed. The actions of adenine nucleotides and nucleosides on cardiomyocytes, atrioventricular and sinoatrial nodes, cardiac fibroblasts, and coronary blood vessels are described. Cardiac release and degradation of ATP are also described. Finally, the involvement of purinergic signalling and its therapeutic potential in cardiac pathophysiology is reviewed, including acute and chronic heart failure, ischemia, infarction, arrhythmias, cardiomyopathy, syncope, hypertrophy, coronary artery disease, angina, diabetic cardiomyopathy, as well as heart transplantation and coronary bypass grafts.
本综述是关于心脏中嘌呤能信号传导的历史记述，旨在让读者了解随着新实验结果的发表，相关观点和认识是如何变化的。最初，重点是作为共递质的ATP在交感神经、副交感神经、感觉神经以及心内神经元中对心脏的神经控制。还讨论了大脑中枢对心脏的控制以及涉及嘌呤的迷走心血管反射。描述了腺嘌呤核苷酸和核苷对心肌细胞、房室结和窦房结、心脏成纤维细胞以及冠状动脉血管的作用。还描述了心脏中ATP的释放和降解。最后，综述了嘌呤能信号传导在心脏病理生理学中的参与情况及其治疗潜力，包括急性和慢性心力衰竭、缺血、梗死、心律失常、心肌病、晕厥、肥大、冠状动脉疾病、心绞痛、糖尿病心肌病，以及心脏移植和冠状动脉搭桥术。
