Walker Elizabeth Reisinger, Druss Benjamin G
Department of Health Policy and Management, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA, 30322, USA,
Community Ment Health J. 2015 Aug;51(6):701-7. doi: 10.1007/s10597-014-9793-9. Epub 2014 Dec 20.
This study examined predictors of persistent major depressive disorder over 10 years, focusing on the effects of clinical variables, physical health, and social support. Data from the National Survey of Midlife Development in the United States in 1995-1996 and 2004-2006 were analyzed. Logistic regression was used to predict non-recovery from major depression among individuals who met clinical-based criteria for major depressive disorder at baseline. Fifteen percent of the total sample was classified as having major depression in 1995-1996; of these individuals, 37 % had major depression in 2004-2006. Baseline variables that were significantly associated with persistent major depression at follow-up were being female, having never married, having two or more chronic medical conditions, experiencing activity limitation, and less contact with family. Therefore, treatment strategies focused on physical health, social support, and mental health needs are necessary to comprehensively address the factors that contribute to persistent major depressive disorder.
本研究调查了10年间持续性重度抑郁症的预测因素，重点关注临床变量、身体健康和社会支持的影响。分析了来自1995 - 1996年和2004 - 2006年美国中年发展全国性调查的数据。逻辑回归用于预测在基线时符合重度抑郁症临床标准的个体中重度抑郁症未康复的情况。在1995 - 1996年，总样本的15%被归类为患有重度抑郁症；在这些个体中，37%在2004 - 2006年患有重度抑郁症。与随访时持续性重度抑郁症显著相关的基线变量包括女性、从未结婚、患有两种或更多慢性疾病、存在活动受限以及与家人联系较少。因此，需要针对身体健康、社会支持和心理健康需求的治疗策略，以全面解决导致持续性重度抑郁症的因素。
