From the Unit of Nutritional Epidemiology, Institute of Environmental Medicine (VO, NO, OS-A, and AW) and the Unit of Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery (OS-A), Karolinska Institutet, Stockholm, Sweden.
Am J Clin Nutr. 2015 Jan;101(1):72-8. doi: 10.3945/ajcn.113.076174. Epub 2014 Nov 5.
Epidemiologic data on the role of diet in acute pancreatitis are sparse.
We examined the association of total fish consumption, as well as of consumption of fatty fish and lean fish separately, with risk of non-gallstone-related acute pancreatitis.
We used data from 2 prospective cohorts, the Cohort of Swedish Men and the Swedish Mammography Cohort, that included 39,267 men and 32,191 women who were aged 45-84 y at the start of a 13-y follow-up period (1998-2010). Fish consumption was assessed by using a food-frequency questionnaire at baseline, and cases of incident non-gallstone-related acute pancreatitis were identified by linkage to the Swedish National Patient Register. HRs were estimated by using Cox proportional hazard models.
During a total follow-up of 860,176 person-years, 320 cases (209 cases in men and 111 cases in women) of incident non-gallstone-related acute pancreatitis were identified. We observed that total fish consumption ≤2.0-3.0 servings/wk was associated with a significantly decreased risk of the disease (P-nonlinearity = 0.017). In comparison with 0.9 servings/wk, multivariable-adjusted HRs were 0.86 (95% CI: 0.76, 0.96), 0.77 (95% CI: 0.62, 0.96), and 0.85 (95% CI: 0.65, 1.10) for 1.4, 2.4, and 3.5 servings/wk, respectively. In the analysis of fatty fish and lean fish, we observed that the consumption of each subtype had a similarly shaped association with risk of non-gallstone-related acute pancreatitis as that observed for total fish consumption, although neither was significant. Multivariable-adjusted HRs were 0.83 for fatty fish (95% CI: 0.65, 1.04) and 0.87 for lean fish (95% CI: 0.69, 1.11) when 0.6-2.0 servings/wk was compared with ≤0.5 servings/wk.
Our data suggest that the consumption of total fish (fatty fish and lean fish combined) may be associated with decreased risk of non-gallstone-related acute pancreatitis.
关于饮食在急性胰腺炎中作用的流行病学数据很少。
我们研究了总鱼摄入量，以及分别摄入高脂肪鱼和低脂肪鱼与非胆石性急性胰腺炎风险之间的关系。
我们使用了来自两个前瞻性队列（瑞典男性队列和瑞典乳腺 X 线摄影队列）的数据，这些队列包括 39267 名男性和 32191 名女性，他们在 13 年的随访期间（1998-2010 年）年龄在 45-84 岁之间。在基线时使用食物频率问卷评估鱼类摄入量，通过与瑞典国家患者登记册的链接确定非胆石性急性胰腺炎的发病情况。使用 Cox 比例风险模型估计 HR。
在总共 860176 人年的随访期间，发现了 320 例（209 例男性和 111 例女性）非胆石性急性胰腺炎的新发病例。我们发现，每周摄入 2-3 份鱼或以下的鱼类与疾病风险显著降低有关（P-非线性=0.017）。与每周摄入 0.9 份相比，多变量调整后的 HR 分别为 0.86（95%CI：0.76，0.96）、0.77（95%CI：0.62，0.96）和 0.85（95%CI：0.65，1.10）。每周摄入 1.4、2.4 和 3.5 份鱼时，分别对应 0.86、0.77 和 0.85。在对高脂肪鱼和低脂肪鱼的分析中，我们观察到每种亚型的摄入量与非胆石性急性胰腺炎的风险之间呈相似的关联，尽管都没有统计学意义。与每周摄入≤0.5 份相比，每周摄入 0.6-2.0 份时，高脂肪鱼的多变量调整 HR 为 0.83（95%CI：0.65，1.04），低脂肪鱼的 HR 为 0.87（95%CI：0.69，1.11）。
我们的数据表明，总鱼（高脂肪鱼和低脂肪鱼的组合）的摄入可能与非胆石性急性胰腺炎的风险降低有关。
