Nulman Irena
J Popul Ther Clin Pharmacol. 2014;21(3):e542-7. Epub 2014 Dec 11.
Second generation antipsychotics are widely used by thousands of pregnant women worldwide in order to control their psychiatric disorders. The clinical profiles of these drugs have improved, specifically the decreased risk of hyperprolactinemia, which has increased fertility in female patients. However, the reproductive safety of second generation antipsychotics remains undefined and controversial. The aim of this presentation is to synthesize the available evidence-based information into a systematic review of the safety in pregnancy of this group of drugs (in mono-and polytherapy).
全球数以千计的孕妇广泛使用第二代抗精神病药物来控制她们的精神疾病。这些药物的临床特征有所改善，特别是高泌乳素血症风险降低，这提高了女性患者的生育能力。然而，第二代抗精神病药物的生殖安全性仍不明确且存在争议。本报告的目的是将现有的循证信息综合起来，对这类药物（单药治疗和联合治疗）在孕期的安全性进行系统综述。
