Wang Weiye, Xu Suowen, Yin Meimei, Jin Zheng Gen
Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA.
Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA.
Int J Cardiol. 2015 Feb 15;181:180-4. doi: 10.1016/j.ijcard.2014.10.148. Epub 2014 Oct 24.
Growth factors and their downstream receptor tyrosine kinases (RTKs) mediate a number of biological processes controlling cell function. Adaptor (docking) proteins, which consist exclusively of domains and motifs that mediate molecular interactions, link receptor activation to downstream effectors. Recent studies have revealed that Grb2-associated-binders (Gab) family members (including Gab1, Gab2, and Gab3), when phosphorylated on tyrosine residues, provide binding sites for multiple effector proteins, such as Src homology-2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2) and phosphatidylinositol 3-kinase (PI3K) regulatory subunit p85, thereby playing important roles in transducing RTKs-mediated signals into pathways with diversified biological functions. Here, we provide an up-to-date overview on the domain structure and biological functions of Gab1, the most intensively studied Gab family protein, in growth factor signaling and biological functions, with a special focus on angiogenesis.
生长因子及其下游受体酪氨酸激酶（RTK）介导许多控制细胞功能的生物学过程。衔接子（对接）蛋白仅由介导分子相互作用的结构域和基序组成，将受体激活与下游效应器联系起来。最近的研究表明，Grb2相关结合蛋白（Gab）家族成员（包括Gab1、Gab2和Gab3）在酪氨酸残基上磷酸化时，为多种效应蛋白提供结合位点，如含Src同源2（SH2）结构域的蛋白酪氨酸磷酸酶2（SHP2）和磷脂酰肌醇3激酶（PI3K）调节亚基p85，从而在将RTK介导的信号转导到具有多种生物学功能的途径中发挥重要作用。在此，我们提供了关于Gab1（研究最深入的Gab家族蛋白）在生长因子信号传导和生物学功能方面的结构域结构和生物学功能的最新综述，特别关注血管生成。
