Innocenti Francesca, Del Taglia Beatrice, Coppa Alessandro, Trausi Federica, Conti Alberto, Zanobetti Maurizio, Pini Riccardo
High-Dependency Unit, Department of Clinical and Experimental Medicine, Azienda Ospedaliero-Universitaria Careggi, Firenze, Italy.
High-Dependency Unit, Department of Clinical and Experimental Medicine, Azienda Ospedaliero-Universitaria Careggi, Firenze, Italy.
Injury. 2015 May;46(5):902-8. doi: 10.1016/j.injury.2014.11.033. Epub 2014 Nov 29.
To evaluate potential reduction in health-related quality of life (HRQOL) after a mild to moderate trauma.
Follow-up study of a cohort of 153 trauma patients admitted to the High Dependency Unit of the Emergency Department of the University-Hospital of Florence from July 2008 to February 2012. After 6 months from the event, a telephone interview using the Physical (PCS) and Mental (MCS) Health Composite Score (SF12) was conducted. Patients reported their HRQOL both at present and before trauma. Scores ≥ 50 represent no disability; 40-49, mild disability; 30-39, moderate disability; and below 30, severe disability.
Before the event 143 (93%) subjects reported a normal PCS and MCS. After the events, a significantly lower proportion of patients maintained a normal PCS and MCS values (52 and 68%, all p<0.01). One, two, three and four PCS items worsened in 14%, 15%, 18% and 38% of the study population, while one, two, three or four MCS dimensions worsened in 12%, 19%, 19% and 24%. We identified 109 subjects (N+), which showed normal PCS and MCS values before trauma, in the absence of any pre-existing medical condition. After the event, we observed a significant PCS (before: 54, standard deviation, SD 6; after 43, SD 11, p<0.0001) and MCS (before: 55, SD 7; after 47, SD 11, p<0.0001) worsening among N+ subjects. Distribution across the four disability categories was 52, 24, 17 and 6% for MCS score and 38, 25, 27 and 11% for PCS score: overall 8 (7%) patients reported a moderate disability and 5 (5%) reported a severe disability in both dimensions. Compared with subjects with preserved values, patients with an abnormal (<39) HRQOL were older, showed a higher prevalence of female gender and pre-existing medical conditions and a worst Sequential Organ Failure Assessment score. An advanced age (OR 1.033, 95% CI 1.010-1.057, p=0.005) and a higher SOFA T1 score (OR 1.500, 95% CI 1.027-2.190, p=0.036) were independently associated with a worsening PCS.
After a mild trauma, we evidenced a relevant reduction in HRQOL; an advanced age and a higher degree of organ dysfunction were independently associated with HRQOL deterioration.
评估轻度至中度创伤后健康相关生活质量(HRQOL)的潜在降低情况。
对2008年7月至2012年2月期间入住佛罗伦萨大学医院急诊科高依赖病房的153名创伤患者进行队列随访研究。事件发生6个月后,通过电话访谈使用躯体健康综合评分(PCS)和精神健康综合评分(MCS)(SF12)。患者报告了他们目前以及创伤前的HRQOL。得分≥50表示无残疾;40 - 49为轻度残疾;30 - 39为中度残疾;低于30为重度残疾。
事件发生前,143名(93%)受试者报告PCS和MCS正常。事件发生后,维持PCS和MCS正常数值的患者比例显著降低(分别为52%和68%,均p<0.01)。研究人群中,PCS的一、二、三、四项指标恶化的比例分别为14%、15%、18%和38%,而MCS的一、二、三、四个维度恶化的比例分别为12%、19%、19%和24%。我们确定了109名受试者(N+),他们在创伤前PCS和MCS值正常,且不存在任何既往病史。事件发生后,我们观察到N+受试者的PCS(创伤前:54,标准差,SD 6;创伤后43,SD 11,p<0.0001)和MCS(创伤前:55,SD 7;创伤后4七,SD 11,p<0.0001)显著恶化。MCS评分在四个残疾类别中的分布分别为52%、24%、17%和6%,PCS评分为38%、25%、27%和11%:总体而言,8名(7%)患者在两个维度上均报告为中度残疾,5名(5%)报告为重度残疾。与数值保持正常的受试者相比,HRQOL异常(<39)的患者年龄更大,女性及既往病史的患病率更高,序贯器官衰竭评估评分更差。高龄(OR 1.033,95%CI 1.010 - 1.057,p = 0.005)和更高的SOFA T1评分(OR 1.500,95%CI 1.027 - 2.190,p = 0.036)与PCS恶化独立相关。
轻度创伤后,我们证明HRQOL有显著降低;高龄和更高程度的器官功能障碍与HRQOL恶化独立相关。