Matyjaszek-Matuszek Beata, Lenart-Lipińska Monika, Kowalczyk-Bołtuć Jolanta, Wożniak Sławomir, Paszkowski Tomasz
Chair and Department of Endocrinology, Medical University of Lublin.
Department of Laboratory Diagnostics, Medical University of Lublin.
Ann Agric Environ Med. 2014;21(4):850-3. doi: 10.5604/12321966.1129945.
Current literature provides contradictory information on the role of adiponectin (AdipoQ) in the course of gestational diabetes mellitus (GDM) and the changes after delivery. The aim of the study was to measure AdipoQ concentration in blood of women with GDM, and to conduct a comparative analysis of AdipoQ concentrations in gestation at 3 and 12 months after delivery.
The study group consisted of 50 women diagnosed with GDM between 24 and 28 weeks of gestation. Three months after delivery, 41 women underwent further tests, while 12 months after delivery 30 patients. All patients underwent clinical and laboratory evaluation at GDM diagnosis at 3 and 12 months after delivery. Laboratory evaluation included fasting glucose, fasting insulin, OGTT and lipid parameters in serum. Serum AdipoQ concentration was measured at GDM diagnosis as well as at 3 and 12 months after delivery.
AdipoQ concentrations did not differ significantly between the groups during gestation (p=0.7054) and 3 months after delivery (p=0.9732), while a significant rise was observed 12 months after delivery, compared to the values during pregnancy (p=0.0006). AdipoQ in the GDM group 12 months after delivery inversely correlated with fasting glucose and 2-hour post-load plasma glucose after a 75-g oral glucose tolerance test (r=-0.37*; p<0.05 and r=-0.42, p<0.05, respectively).
An increased level of AdipoQ after delivery in the comparison to women with GDM may be a marker for reversibility of carbohydrate metabolism disorders, while a negative correlation between AdipoQ and glucose levels suggests that this parameter may be a predictor In the future of disturbances in glucose tolerance in women with GDM.
当前文献关于脂联素（AdipoQ）在妊娠期糖尿病（GDM）病程及产后变化中的作用提供了相互矛盾的信息。本研究的目的是测定GDM女性血液中的AdipoQ浓度，并对产后3个月和12个月时妊娠期的AdipoQ浓度进行比较分析。
研究组由50例在妊娠24至28周期间被诊断为GDM的女性组成。产后3个月，41名女性接受了进一步检查，产后12个月有30名患者接受检查。所有患者在GDM诊断时、产后3个月和12个月均接受了临床和实验室评估。实验室评估包括空腹血糖、空腹胰岛素、口服葡萄糖耐量试验（OGTT）及血清脂质参数。在GDM诊断时以及产后3个月和12个月测定血清AdipoQ浓度。
各组在妊娠期（p = 0.7054）和产后3个月（p = 0.9732）时AdipoQ浓度无显著差异，而与孕期值相比，产后12个月时观察到显著升高（p = 0.0006）。产后12个月时GDM组的AdipoQ与空腹血糖以及75克口服葡萄糖耐量试验后2小时血糖呈负相关（r = -0.37*；p < 0.05和r = -0.42，p < 0.05）。
与GDM女性相比，产后AdipoQ水平升高可能是碳水化合物代谢紊乱可逆性的一个标志物，而AdipoQ与血糖水平之间的负相关表明该参数可能是未来GDM女性糖耐量异常的一个预测指标。
