Pala Halil G, Ozalp Yılmaz, Yener Abdullah S, Gerceklioglu Gul, Uysal Sezer, Onvural Ata
Department of Obstetrics and Gynecology, Perinatology Division, Celal Bayar University, School of Medicine, Manisa, Turkey.
Elbistan Government Hospital, Kahramanmaras, Turkey.
Adv Clin Exp Med. 2015 Jan-Feb;24(1):85-92. doi: 10.17219/acem/38141.
The aim of the study was to determine serum adiponectin levels among patients with gestational diabetes mellitus (GDM) and normal pregnant women without glucose intolerance, and to investigate the relationship between these levels and clinical factors at the time of the diagnosis, at delivery and in the post-partum period.
The subjects' serum adiponectin concentration was measured using the enzyme-linked immunosorbent assay (ELISA) method at 24th-28th week of gestation, at delivery (in maternal circulation and the umbilical cord) and 24 h after delivery. The relationship between these groups' measurements and other established clinical-laboratory factors were investigated.
Serum adiponectin concentrations were significantly lower (p = 0.02) in GDM patients compared with patients with normal glucose tolerance at 24th-28th week of gestation. During delivery, maternal serum adiponectin concentrations were significantly lower (p = 0.03) in GDM patients compared with patients with normal glucose tolerance. In the post-partum period, serum adiponectin concentrations were significantly higher (p = 0.009) in GDM patients compared with patients with normal glucose tolerance. Umbilical cord adiponectin concentrations were significantly lower (p = 0.005) in GDM patients compared with patients with normal glucose tolerance.
Adiponectin concentrations in GDM patients' circulation were regulated by changes in glucose and insulin metabolism. A reduction in serum adiponectin levels seems to play a role in GDM patients' insulin resistance.
本研究旨在测定妊娠期糖尿病（GDM）患者和无葡萄糖不耐受的正常孕妇的血清脂联素水平，并探讨这些水平与诊断时、分娩时及产后临床因素之间的关系。
在妊娠第24 - 28周、分娩时（母体循环和脐带血）及产后24小时，采用酶联免疫吸附测定（ELISA）法测量受试者血清脂联素浓度。研究了这些组别的测量值与其他既定临床实验室因素之间的关系。
在妊娠第24 - 28周时，GDM患者的血清脂联素浓度显著低于糖耐量正常的患者（p = 0.02）。分娩时，GDM患者的母体血清脂联素浓度显著低于糖耐量正常的患者（p = 0.03）。在产后，GDM患者的血清脂联素浓度显著高于糖耐量正常的患者（p = 0.009）。GDM患者的脐带血脂联素浓度显著低于糖耐量正常的患者（p = 0.005）。
GDM患者循环中的脂联素浓度受葡萄糖和胰岛素代谢变化的调节。血清脂联素水平降低似乎在GDM患者的胰岛素抵抗中起作用。
