Ferlito A, Friedmann I
Department of Otolaryngology, Padua-University, Italy.
Ann Otol Rhinol Laryngol. 1989 Oct;98(10):780-90. doi: 10.1177/000348948909801006.
Neuroendocrine carcinomas of the larynx are uncommon tumors of considerable scientific interest and clinical importance. They include typical carcinoid tumors, atypical carcinoid tumors, and small cell neuroendocrine carcinomas. This paper considers these neoplasms from a personal experience and reviews the relevant medical literature. About 200 cases of neuroendocrine carcinomas of the larynx have been reported. The diagnosis is based on light microscopy and is confirmed by ultrastructural evidence of neurosecretory granules. Histochemical and immunocytochemical investigations may support it. Paraneoplastic syndromes associated with laryngeal neuroendocrine carcinomas have been reported occasionally. The histogenesis, treatment, and prognosis of these lesions also are discussed.
喉神经内分泌癌是一类罕见的肿瘤，具有相当大的科学研究价值和临床重要性。它们包括典型类癌、非典型类癌和小细胞神经内分泌癌。本文结合个人经验对这些肿瘤进行探讨，并复习相关医学文献。喉神经内分泌癌已报道约200例。诊断基于光镜检查，并通过神经分泌颗粒的超微结构证据得以证实。组织化学和免疫细胞化学研究可提供支持。与喉神经内分泌癌相关的副肿瘤综合征偶有报道。本文还讨论了这些病变的组织发生、治疗及预后。
