López F, Hunt J L, Nixon I J, Rinaldo A, Williams M D, Cardesa A, Ferlito A
Department of Otolaryngology,Hospital Universitario Central de Asturias,Oviedo,Spain.
Department of Pathology,University of Arkansas for Medical Sciences,Little Rock,USA.
J Laryngol Otol. 2018 Jul;132(7):568-574. doi: 10.1017/S0022215118000968. Epub 2018 Jun 18.
This review aimed to critically analyse data pertaining to the clinical presentation and treatment of neuroendocrine carcinomas of the larynx.
A PubMed search was performed using the term 'neuroendocrine carcinoma'. English-language articles on neuroendocrine carcinoma of the larynx were reviewed in detail.Results and conclusionWhile many historical classifications have been proposed, in contemporary practice these tumours are sub-classified into four subtypes: carcinoid, atypical carcinoid, small cell neuroendocrine carcinoma and large cell neuroendocrine carcinoma. These tumours exhibit a wide range of biological behaviour, ranging from the extremely aggressive nature of small and large cell neuroendocrine carcinomas, which usually have a fatal prognosis, to the less aggressive course of carcinoid tumours. In small and large cell neuroendocrine carcinomas, a combination of irradiation and chemotherapy is indicated, while carcinoid and atypical carcinoid tumour management entails conservation surgery.
本综述旨在批判性分析有关喉神经内分泌癌临床表现及治疗的数据。
使用“神经内分泌癌”一词在PubMed上进行检索。对有关喉神经内分泌癌的英文文章进行了详细综述。
虽然已经提出了许多历史分类方法，但在当代实践中，这些肿瘤被细分为四种亚型：类癌、非典型类癌、小细胞神经内分泌癌和大细胞神经内分泌癌。这些肿瘤表现出广泛的生物学行为，从小细胞和大细胞神经内分泌癌的极具侵袭性（通常预后不良）到类癌肿瘤侵袭性较小的病程不等。对于小细胞和大细胞神经内分泌癌，建议采用放疗和化疗相结合的方法，而类癌和非典型类癌肿瘤的治疗则需要进行保留手术。
