Liver Institute of Virginia, Bon Secours Health System, Richmond and Newport News, Virginia, USA.
Liver Int. 2015 Jan;35 Suppl 1:71-7. doi: 10.1111/liv.12734.
Chronic hepatitis C virus (HCV) causes chronic liver injury and can lead to cirrhosis and hepatocellular carcinoma (HCC). HCV can also interact with the immune system to cause several HCV related disorders including essential mixed cryoglobulinemia, vasculitis, dermatitis, glomerulonephritis and lymphoma. A strong association between HCV and diabetes mellitus also exists. These extrahepatic features may lead to increased fatigue and a reduced quality of life. It is now possible to cure most patients with chronic HCV using oral antiviral therapy. Many of these HCV-related disorders and symptoms can be cured when HCV is eradicated. However, some patients may have irreversible injury to extrahepatic sites, cirrhosis that cannot resolve, an increased risk for HCC, persistent fatigue and a reduced quality of life, despite achieving sustained virological response.
慢性丙型肝炎病毒（HCV）可引起慢性肝损伤，并可导致肝硬化和肝细胞癌（HCC）。HCV 还可以与免疫系统相互作用，导致几种与 HCV 相关的疾病，包括原发性混合性冷球蛋白血症、血管炎、皮炎、肾小球肾炎和淋巴瘤。HCV 与糖尿病之间也存在很强的关联。这些肝外特征可能导致疲劳加重和生活质量降低。目前，使用口服抗病毒治疗可以治愈大多数慢性 HCV 患者。当 HCV 被根除时，许多与 HCV 相关的疾病和症状都可以治愈。然而，尽管实现了持续病毒学应答，一些患者可能仍有肝外部位的不可逆转损伤、无法消退的肝硬化、HCC 的风险增加、持续疲劳和生活质量降低。
