Department of Mathematics, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Phys Life Rev. 2015 Mar;12:44-64. doi: 10.1016/j.plrev.2014.12.002. Epub 2014 Dec 5.
This paper proposes a critical analysis of the existing literature on mathematical tools developed toward systems biology approaches and, out of this overview, develops a new approach whose main features can be briefly summarized as follows: derivation of mathematical structures suitable to capture the complexity of biological, hence living, systems, modeling, by appropriate mathematical tools, Darwinian type dynamics, namely mutations followed by selection and evolution. Moreover, multiscale methods to move from genes to cells, and from cells to tissue are analyzed in view of a new systems biology approach.
本文对现有的系统生物学方法中开发的数学工具文献进行了批判性分析，并在此基础上提出了一种新方法，其主要特点可简要概括为以下几点：推导适合于捕捉生物（即有生命的）系统复杂性的数学结构，通过适当的数学工具，对达尔文类型的动态（即突变后选择和进化）进行建模。此外，还分析了从基因到细胞、从细胞到组织的多尺度方法，以期建立新的系统生物学方法。
