Multiscale in Mechanical and Biological Engineering (M2BE), Aragon Institute of Engineering Research (I3A), Zaragoza, Spain.
Department of Mechanical Engineering, University of Zaragoza, Zaragoza, Spain.
Cell Adh Migr. 2022 Dec;16(1):25-64. doi: 10.1080/19336918.2022.2055520.
Cell motility is essential for life and development. Unfortunately, cell migration is also linked to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies on many actors. Cells change their migratory strategy based on their phenotype and the properties of the surrounding microenvironment. Cell migration is, therefore, an extremely complex phenomenon. Researchers have investigated cell motility for more than a century. Recent discoveries have uncovered some of the mysteries associated with the mechanisms involved in cell migration, such as intracellular signaling and cell mechanics. These findings involve different players, including transmembrane receptors, adhesive complexes, cytoskeletal components , the nucleus, and the extracellular matrix. This review aims to give a global overview of our current understanding of cell migration.
细胞运动对于生命和发育至关重要。不幸的是，细胞迁移也与几种病理过程有关，如癌症转移。细胞迁移的能力依赖于许多因素。细胞根据其表型和周围微环境的特性改变其迁移策略。因此，细胞迁移是一个极其复杂的现象。研究人员对细胞运动进行了一个多世纪的研究。最近的发现揭示了一些与细胞迁移相关机制的奥秘，如细胞内信号转导和细胞力学。这些发现涉及不同的参与者，包括跨膜受体、黏附复合物、细胞骨架成分、细胞核和细胞外基质。这篇综述旨在全面概述我们目前对细胞迁移的理解。
