Hullah E A, Blaker P A, Marinaki A M, Escudier M P, Sanderson J D
Oral Medicine, King's College London Dental Institute, London, UK.
Gastroenterology, Guy's & St Thomas' Hospitals NHS Foundation Trust, Guy's Hospital, Great Maze Pond, London, UK.
J Oral Pathol Med. 2015 Nov;44(10):761-8. doi: 10.1111/jop.12274. Epub 2014 Dec 19.
Thiopurines are widely used as first-line immunosuppressive therapies in the management of chronic inflammatory oral disease. However, despite over half a century of clinical experience, the evidence base for their use is limited. The aims of this paper were to review the evidence for the use of thiopurines in oral medicine and provide a contemporary model of thiopurine metabolism and mechanism of action and a rationale for clinical use and safe practice.
硫唑嘌呤类药物作为慢性炎症性口腔疾病管理中的一线免疫抑制疗法被广泛使用。然而，尽管有半个多世纪的临床经验，其使用的证据基础仍然有限。本文的目的是回顾硫唑嘌呤类药物在口腔医学中使用的证据，并提供硫唑嘌呤代谢和作用机制的当代模型以及临床使用和安全实践的基本原理。
