Department of Gastroenterology and Hepatology, VU University Medical Centre, Amsterdam, The Netherlands.
Department of Gastroenterology and Hepatology and Inserm U954, Nancy University Hospital, Lorraine University, Vandoeuvre-lès-Nancy, France.
J Crohns Colitis. 2018 Apr 27;12(5):610-620. doi: 10.1093/ecco-jcc/jjx181.
Thiopurines, available as azathioprine, mercaptopurine, and thioguanine, are immunomodulating agents primarily used to maintain corticosteroid-free remission in patients with inflammatory bowel disease. To provide a state-of-the-art overview of thiopurine treatment in inflammatory bowel disease, this clinical review critically summarises the available literature, as assessed by several experts in the field of thiopurine treatment and research in inflammatory bowel disease.
硫嘌呤类药物有硫唑嘌呤、巯嘌呤和硫鸟嘌呤，是免疫调节剂，主要用于维持炎症性肠病患者的皮质类固醇激素缓解。为了提供炎症性肠病中硫嘌呤治疗的最新概述，本临床综述批判性地总结了该领域的几位专家评估的现有文献，以及炎症性肠病中硫嘌呤治疗和研究的专家。
