Department of Sciences, University Roma Tre, Rome, Italy.
Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Italy.
Cytokine Growth Factor Rev. 2015 Apr;26(2):159-73. doi: 10.1016/j.cytogfr.2014.11.010. Epub 2014 Nov 29.
Several viruses manipulate host innate immune responses to avoid immune recognition and improve viral replication and spreading. The viral protein Nef of Human Immunodeficiency Virus is mainly involved in this "hijacking" activity and is a well established virulence factor. In the last few years there have been remarkable advances in outlining a defined framework of its functions. In particular Nef appears to be a shuttling molecular adaptor able to exert its effects both on infected and non infected bystander cell. In addition it is emerging fact that it has an important impact on the chemo-cytokine network. Nef protein represents an interesting new target to develop therapeutic drugs for treatment of seropositive patients. In this review we have tried to provide a unifying view of the multiple functions of this viral protein on the basis of recently available experimental data.
几种病毒操纵宿主先天免疫反应以避免免疫识别，并提高病毒复制和传播。人类免疫缺陷病毒的病毒蛋白 Nef 主要参与这种“劫持”活动，是一种公认的毒力因子。在过去的几年中，人们在概述其功能的明确框架方面取得了显著进展。特别是，Nef 似乎是一种穿梭分子衔接子，能够在感染和未感染的旁观者细胞上发挥作用。此外，事实证明，它对趋化因子网络有重要影响。Nef 蛋白代表了一个有趣的新靶点，可用于开发治疗血清阳性患者的治疗药物。在这篇综述中，我们试图根据最近获得的实验数据，对这种病毒蛋白的多种功能提供一个统一的观点。
