• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

将营养性酮症作为治愈小儿大脑的一种选择提出来讨论。

Bringing nutritional ketosis to the table as an option for healing the pediatric brain.

作者信息

Gertler Tracy S, Blackford Robyn

机构信息

Division of Pediatric Neurology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States.

Division of Clinical Nutrition, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States.

出版信息

Front Nutr. 2024 Jun 12;11:1408327. doi: 10.3389/fnut.2024.1408327. eCollection 2024.

DOI:10.3389/fnut.2024.1408327
PMID:38933892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11199727/
Abstract

Our core premise is that personalized variations of a ketogenic diet are likely to benefit pediatric patients with neuropsychiatric symptoms across multiple domains. Although pediatric epilepsy is currently a well-accepted indication for a strict ketogenic diet, there is a dearth of knowledge and therefore clinical guidelines upon which to recommend nutritional ketosis for pervasive pediatric conditions such as autism spectrum disorder and ADHD, even when comorbid epilepsy is present. However, there are published cohort studies and current clinical trials implementing medical ketogenic therapies for cognitive impairment, psychiatric comorbidities, motor disability, and even neuroinflammation. As holistic practitioners, it is imperative that we consider the health of a child in its entirety - and additionally offer the ketogenic diet as a therapeutic option when it may be synergistic in treating extra-neurologic diseases such as obesity. While there are uniquely pediatric potential adverse side effects such as linear growth deceleration and micronutrient deficiencies, previous trials in epilepsy and our center's experience have already proven the ketogenic diet to be a low-risk intervention when optimized with appropriate patient monitoring and support.

摘要

我们的核心前提是,生酮饮食的个性化变体可能会在多个领域使患有神经精神症状的儿科患者受益。虽然儿科癫痫目前是严格生酮饮食的一个被广泛认可的适应症,但对于自闭症谱系障碍和注意力缺陷多动障碍等普遍存在的儿科疾病,即便存在合并癫痫的情况,在推荐营养性酮症方面仍缺乏相关知识,因此也没有临床指南。然而,有已发表的队列研究以及当前正在进行的临床试验,针对认知障碍、精神共病、运动残疾甚至神经炎症实施医学生酮疗法。作为整体治疗从业者,我们必须全面考虑儿童的健康状况——此外,当生酮饮食在治疗肥胖等神经外疾病时可能具有协同作用时,应将其作为一种治疗选择提供给患者。虽然存在如线性生长减速和微量营养素缺乏等独特的儿科潜在不良副作用,但先前在癫痫方面的试验以及我们中心的经验已经证明,通过适当的患者监测和支持进行优化后,生酮饮食是一种低风险的干预措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c35d/11199727/d9f0591c20e0/fnut-11-1408327-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c35d/11199727/d9f0591c20e0/fnut-11-1408327-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c35d/11199727/d9f0591c20e0/fnut-11-1408327-g001.jpg

相似文献

1
Bringing nutritional ketosis to the table as an option for healing the pediatric brain.将营养性酮症作为治愈小儿大脑的一种选择提出来讨论。
Front Nutr. 2024 Jun 12;11:1408327. doi: 10.3389/fnut.2024.1408327. eCollection 2024.
2
Ketogenic diets improve behaviors associated with autism spectrum disorder in a sex-specific manner in the EL mouse.生酮饮食以性别特异性方式改善了EL小鼠与自闭症谱系障碍相关的行为。
Physiol Behav. 2017 Jan 1;168:138-145. doi: 10.1016/j.physbeh.2016.10.023. Epub 2016 Nov 9.
3
Does the ketogenic ratio matter when using ketogenic diet therapy in pediatric epilepsy?在小儿癫痫中使用生酮饮食疗法时,生酮比例重要吗?
Epilepsia. 2023 Feb;64(2):284-291. doi: 10.1111/epi.17476. Epub 2022 Dec 15.
4
Ketogenic diet in children and adolescents: The effects on growth and nutritional status.儿童和青少年生酮饮食:对生长和营养状况的影响。
Pharmacol Res. 2023 May;191:106780. doi: 10.1016/j.phrs.2023.106780. Epub 2023 Apr 22.
5
The Modified Atkins Diet for Epilepsy: Two Decades of an "Alternative" Ketogenic Diet Therapy.用于癫痫治疗的改良阿特金斯饮食:二十年的“另类”生酮饮食疗法。
Pediatr Neurol. 2023 Oct;147:82-87. doi: 10.1016/j.pediatrneurol.2023.07.014. Epub 2023 Jul 22.
6
Reducing Prescribing Errors in Hospitalized Children on the Ketogenic Diet.减少接受生酮饮食治疗的住院儿童的处方错误。
Pediatr Neurol. 2021 Feb;115:42-47. doi: 10.1016/j.pediatrneurol.2020.11.009. Epub 2020 Nov 22.
7
The Relationship of Ketogenic Diet with Neurodegenerative and Psychiatric Diseases: A Scoping Review from Basic Research to Clinical Practice.生酮饮食与神经退行性和精神疾病的关系:从基础研究到临床实践的范围综述。
Nutrients. 2023 May 11;15(10):2270. doi: 10.3390/nu15102270.
8
Valproate effect on ketosis in children under ketogenic diet.丙戊酸盐对生酮饮食儿童酮症的影响。
Eur J Paediatr Neurol. 2016 Jul;20(4):555-9. doi: 10.1016/j.ejpn.2016.04.003. Epub 2016 Apr 13.
9
Nutritional Ketosis in Parkinson's Disease - a Review of Remaining Questions and Insights.帕金森病中的营养性酮症——尚存问题与新见解的综述。
Neurotherapeutics. 2021 Jul;18(3):1637-1649. doi: 10.1007/s13311-021-01067-w. Epub 2021 Jul 7.
10
An overview of the ketogenic diet for pediatric epilepsy.儿童癫痫生酮饮食概述。
Nutr Clin Pract. 2008;23(6):589-96. doi: 10.1177/0884533608326138.

本文引用的文献

1
The Modified Atkins Diet for Epilepsy: Two Decades of an "Alternative" Ketogenic Diet Therapy.用于癫痫治疗的改良阿特金斯饮食:二十年的“另类”生酮饮食疗法。
Pediatr Neurol. 2023 Oct;147:82-87. doi: 10.1016/j.pediatrneurol.2023.07.014. Epub 2023 Jul 22.
2
The Relationship of Ketogenic Diet with Neurodegenerative and Psychiatric Diseases: A Scoping Review from Basic Research to Clinical Practice.生酮饮食与神经退行性和精神疾病的关系:从基础研究到临床实践的范围综述。
Nutrients. 2023 May 11;15(10):2270. doi: 10.3390/nu15102270.
3
Accelerated hypometabolism with disease progression associated with faster cognitive decline among amyloid positive patients.
淀粉样蛋白阳性患者中,随着疾病进展出现的加速性低代谢与更快的认知衰退相关。
Front Neurosci. 2023 Apr 14;17:1151820. doi: 10.3389/fnins.2023.1151820. eCollection 2023.
4
The Ketogenic Diet in Children with Epilepsy: A Focus on Parental Stress and Family Compliance. ketogenic 饮食在癫痫患儿中的应用:关注父母压力和家庭顺应性。
Nutrients. 2023 Feb 20;15(4):1058. doi: 10.3390/nu15041058.
5
Down syndrome regression disorder: updates and therapeutic advances.唐氏综合征消退障碍:最新进展与治疗新进展
Curr Opin Psychiatry. 2023 Mar 1;36(2):96-103. doi: 10.1097/YCO.0000000000000845. Epub 2022 Dec 29.
6
Case report: Ketogenic diet acutely improves cognitive function in patient with Down syndrome and Alzheimer's disease.病例报告:生酮饮食可急性改善唐氏综合征合并阿尔茨海默病患者的认知功能。
Front Psychiatry. 2023 Jan 9;13:1085512. doi: 10.3389/fpsyt.2022.1085512. eCollection 2022.
7
Modified Atkins diet versus ketogenic diet in children with drug-resistant epilepsy: A meta-analysis of comparative studies.改良阿特金斯饮食与酮饮食治疗儿童耐药性癫痫的比较:荟萃分析。
Clin Nutr ESPEN. 2022 Oct;51:112-119. doi: 10.1016/j.clnesp.2022.09.004. Epub 2022 Sep 10.
8
Is there a place for dietetic interventions in adult ADHD?饮食干预在成人注意缺陷多动障碍中有作用吗?
Prog Neuropsychopharmacol Biol Psychiatry. 2022 Dec 20;119:110613. doi: 10.1016/j.pnpbp.2022.110613. Epub 2022 Aug 12.
9
Mental Health Surveillance Among Children - United States, 2013-2019.儿童心理健康监测 - 美国,2013-2019 年。
MMWR Suppl. 2022 Feb 25;71(2):1-42. doi: 10.15585/mmwr.su7102a1.
10
The Ketogenic Effect of Medium-Chain Triacylglycerides.中链甘油三酯的生酮作用
Front Nutr. 2021 Nov 18;8:747284. doi: 10.3389/fnut.2021.747284. eCollection 2021.