Jain A, Singh S N, Singhal P, Sharma M P
Department of Otolaryngology (ENT),Sawai Man Singh Medical College and Attached Group of Hospitals,Jaipur,Rajasthan,India.
J Laryngol Otol. 2015 Jan;129(1):106-9. doi: 10.1017/S002221511400293X. Epub 2014 Dec 22.
Rhabdomyosarcoma is a malignant mesenchymal neoplasm rarely diagnosed in the larynx. Traditionally, it has been treated by radical surgery (i.e. total laryngectomy), followed by radiation and/or chemotherapy. Recent advances suggest that it may be treated with combination therapy comprising high-dose radiation and pulse chemotherapy, with a high success rate.
We report the first documented case of subglottic embryonal rhabdomyosarcoma in an adolescent female treated with chemoradiation alone, and review the literature reflecting a move towards organ preservation.
While surgery has been successfully used to treat this neoplasm, combination therapy, as described in our study, also seems effective and has the added advantage of preserving laryngeal function.
横纹肌肉瘤是一种罕见的发生于喉部的恶性间叶性肿瘤。传统上，其治疗方式为根治性手术（即全喉切除术），随后进行放疗和/或化疗。最近的进展表明，采用大剂量放疗和脉冲化疗的联合疗法治疗横纹肌肉瘤可能具有较高的成功率。
我们报告了首例记录在案的青春期女性声门下胚胎性横纹肌肉瘤患者，该患者仅接受了放化疗，并回顾了反映向器官保留方向发展的文献。
虽然手术已成功用于治疗该肿瘤，但如我们研究中所述的联合疗法似乎也有效，并且具有保留喉功能的额外优势。
