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胚胎性横纹肌肉瘤伪装为左侧声带肉芽肿。

Embryonal rhabdomyosarcoma masquerading as a left vocal cord granuloma.

机构信息

ENT, Central Manchester University Hospitals NHS Foundation Trust, Manchester, Greater Manchester, UK

ENT, Central Manchester University Hospitals NHS Foundation Trust, Manchester, Greater Manchester, UK.

出版信息

BMJ Case Rep. 2020 Oct 30;13(10):e237025. doi: 10.1136/bcr-2020-237025.

Abstract

Embryonal rhabdomyosarcoma (ERMS) of the larynx in adults is an extremely rare diagnosis with insidious onset and progression. Only six reports (including this one) have been documented in the literature. Clinical presentation is dependent on the site, size, subtype of ERMS and growth rate. Hoarseness is the usual first symptom, followed by stridor and dyspnoea, with dysphagia being late in onset. Accurate staging and risk stratification is necessary to avoid overtreating/undertreating patients and should be guided by local Head and Neck/Sarcoma Multidisciplinary Teams. Treatment has moved away from radical therapeutic regimens to less-invasive, organ-preserving therapies. Long-term follow-up is required due to the risk of late recurrence.

摘要

成人喉胚胎性横纹肌肉瘤(ERMS)是一种极为罕见的诊断,其发病隐匿,进展缓慢。文献中仅记载了六例(包括本例)。临床表现取决于 ERMS 的部位、大小、亚型和生长速度。声音嘶哑是常见的首发症状,其次是喘鸣和呼吸困难,吞咽困难出现较晚。准确的分期和危险分层对于避免过度治疗/治疗不足的患者是必要的,应根据当地的头颈部/肉瘤多学科团队来指导。治疗已经从激进的治疗方案转向创伤更小、保留器官的治疗方法。由于存在晚期复发的风险,需要长期随访。

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引用本文的文献

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Incidental Discovery of Embryonal Rhabdomyosarcoma on CT Imaging.CT成像偶然发现胚胎性横纹肌肉瘤
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本文引用的文献

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Rhabdomyosarcoma.横纹肌肉瘤
Semin Pediatr Surg. 2016 Oct;25(5):276-283. doi: 10.1053/j.sempedsurg.2016.09.011. Epub 2016 Sep 20.
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Embryonal Rhabdomyosarcoma of the Adult's Vocal Cord: A Case Report.成人声带胚胎性横纹肌肉瘤:一例报告
Iran Red Crescent Med J. 2015 Aug 26;17(8):e28876. doi: 10.5812/ircmj.28876. eCollection 2015 Aug.
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Sarcoma of the larynx: treatment results and literature review.喉肉瘤:治疗结果及文献综述
J Chin Med Assoc. 2006 Mar;69(3):120-4. doi: 10.1016/S1726-4901(09)70189-3.
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Embryonal rhabdomyosarcoma of the larynx.喉胚胎性横纹肌肉瘤
Otolaryngol Head Neck Surg. 2005 Jul;133(1):160-2. doi: 10.1016/j.otohns.2004.09.115.

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