Vaegter Henrik Bjarke, Handberg Gitte, Jørgensen Maria N, Kinly Anna, Graven-Nielsen Thomas
Pain Center South, University Hospital Odense, Odense, Denmark.
Center for Sensory-Motor Interaction (SMI), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark.
Pain Med. 2015 May;16(5):923-33. doi: 10.1111/pme.12641. Epub 2014 Dec 19.
Physical inactivity is a risk factor for chronic pain. Several mechanisms play a role in pain chronification including impairment of pain inhibition.
This study compared the efficiency of pain inhibitory systems between physical active and inactive healthy subjects. It was hypothesized that active subjects had more efficient pain inhibition compared with inactive subjects.
A randomized, crossover study with 2 days of data collection.
Fifty-six (28 females) subjects participated in this study. Subjects were subgrouped into active (n = 30) and inactive (n = 26). Conditioned pain modulation (CPM) was assessed by cold pressor testing. Exercise-induced hypoalgesia (EIH) was assessed after 15 minutes bicycling at a heart rate corresponding to 75% VO2max. A control session of 15 minutes quiet rest was also included. Pressure pain thresholds (PPTs) were recorded at the dominant arm and leg before, immediately after, and 15 minutes after conditioning and exercise as well as before and after rest. PPTs were also recorded during conditioning.
At baseline, PPTs in inactive men were increased compared with inactive women (P < 0.003). During cold pressor test and after exercise, PPTs increased to the same degree in active and inactive subjects, and the CPM and EIH responses were correlated (P < 0.05). The CPM response immediately after cold pressor test was maintained in women but not in men.
Cold pressor stimulation and aerobic exercise caused comparable multisegmental increases in PPT in active and inactive men and women. The CPM and EIH responses were correlated, but they have different temporal manifestation of hypoalgesia.
身体活动不足是慢性疼痛的一个风险因素。多种机制在疼痛慢性化过程中起作用，包括疼痛抑制功能受损。
本研究比较了身体活动活跃和不活跃的健康受试者之间疼痛抑制系统的效率。研究假设是，与不活跃的受试者相比，活跃的受试者具有更有效的疼痛抑制能力。
一项为期2天数据收集的随机交叉研究。
56名（28名女性）受试者参与了本研究。受试者被分为活跃组（n = 30）和不活跃组（n = 26）。通过冷加压试验评估条件性疼痛调制（CPM）。在以相当于最大摄氧量75%的心率骑自行车15分钟后评估运动诱导的痛觉减退（EIH）。还包括15分钟安静休息的对照时段。在优势手臂和腿部进行预处理、运动后立即、运动后15分钟以及休息前后记录压力疼痛阈值（PPT）。在预处理期间也记录PPT。
在基线时，不活跃男性的PPT高于不活跃女性（P < 0.003）。在冷加压试验期间和运动后，活跃和不活跃受试者的PPT升高程度相同，并且CPM和EIH反应具有相关性（P < 0.05）。冷加压试验后立即出现的CPM反应在女性中持续存在，但在男性中不存在。
冷加压刺激和有氧运动在活跃和不活跃的男性和女性中引起了类似的多节段PPT升高。CPM和EIH反应具有相关性，但它们的痛觉减退有不同的时间表现。
