Musculoskeletal Research Unit, Department of Rehabilitation Sciences, Faculty of Kinesiology and Rehabilitation Sciences, Leuven University, Leuven, Belgium
REVAL Rehabilitation Research Centre, Biomedical Research Institute, Faculty of Rehabilitation Sciences, Hasselt University, Hasselt, Belgium.
BMJ Open. 2024 Jun 18;14(6):e074743. doi: 10.1136/bmjopen-2023-074743.
An endogenous pain modulation profile, reflecting antinociceptive and pronociceptive mechanisms, may help to direct management by targeting the involved pain mechanism. For individuals with cervicogenic headache (CeH), the characteristics of such profiles were never investigated. However, the individual nature of experiencing pain demands profiling within a multidimensional framework including psychosocial lifestyle characteristics. The objective of the current protocol is to assess the pain modulation profile, which includes psychosocial lifestyle characteristics among people with CeH.
A protocol is described to map pain modulation profiles in people with CeH. A cross-sectional non-randomised experimental design will be used to assess feasibility of mapping these profiles. The pain modulation profile is composed based on results on the Depression, Anxiety, Stress Scale, Pittsburgh Sleep Quality Index, Headache Impact Test and on responses to temporal summation of pain (pinprick), conditioned pain modulation and widespread hyperalgesia (mechanical pressure pain threshold and cuff algometry). Primary analyses will report results relating to outcomes on feasibility. Secondary analyses will involve an analysis of proportions (%) of the different psychosocial lifestyle profiles and pain profiles.
Ethical approval was granted by the Ethics Committee Research UZ/KU Leuven (Registration number B3222024001434) on 30 May 2024. Results will be published in peer-reviewed journals, at scientific conferences and, through press releases. Protocol V.3. protocol date: 3 June 2024.
内源性疼痛调制谱反映了抗伤害和伤害感受机制，可能有助于通过针对相关疼痛机制来指导管理。对于颈源性头痛（CeH）患者，从未对这些特征进行过研究。然而，个体体验疼痛的性质要求在包括社会心理生活方式特征在内的多维框架内进行特征分析。本研究方案旨在评估 CeH 患者的疼痛调制谱，其中包括社会心理生活方式特征。
本研究描述了一种用于 CeH 患者疼痛调制谱的映射方案。将使用横断面非随机实验设计来评估映射这些谱的可行性。疼痛调制谱是基于抑郁、焦虑和压力量表、匹兹堡睡眠质量指数、头痛影响测试以及疼痛时间总和（刺痛）、条件性疼痛调制和广泛痛觉过敏（机械压力痛阈和袖带痛觉）的反应结果来构建的。主要分析将报告与可行性结果相关的结果。次要分析将涉及不同社会心理生活方式谱和疼痛谱的比例（%）的分析。
伦理委员会研究 UZ/KU Leuven（注册号 B3222024001434）于 2024 年 5 月 30 日批准了本研究。研究结果将发表在同行评议的期刊上、科学会议上，并通过新闻稿传播。方案版本 V.3.，方案日期：2024 年 6 月 3 日。
