Grigoriadis D E, Pearsall D, De Souza E B
Laboratory of Neurobiology, NIDA Addiction Research Center, Baltimore, MD 21224.
Neuropsychopharmacology. 1989 Mar;2(1):53-60. doi: 10.1016/0893-133x(89)90007-9.
We examined the effects of chronic treatment with antidepressants (imipramine or desipramine) or benzodiazepines (diazepam, alprazolam, or adinazolam) on modulation of corticotropin-releasing-factor (CRF) receptors in discrete areas of rat brain and in anterior pituitary. As previously reported, we found that chronic antidepressant treatment downregulated 5-HT2 serotonin and beta-adrenergic receptors in cerebral cortex. Although there was a trend toward increased CRF binding in brain stem, striatum, cerebellum, hypothalamus, and frontal cerebral cortex following antidepressant treatment, the changes were only statistically significant in brain stem in imipramine-treated rats. In addition, no significant changes were seen in CRF binding in other brain regions including parietal/temporal cerebral cortex, olfactory bulb, hippocampus, and anterior pituitary. Following chronic benzodiazepine treatment CRF receptor binding was significantly decreased in the frontal cerebral cortex and hippocampus; although there was a trend for CRF receptors to be decreased in other brain areas and increased in anterior pituitary, the changes were not statistically significant.
我们研究了用抗抑郁药（丙咪嗪或地昔帕明）或苯二氮䓬类药物（地西泮、阿普唑仑或阿地唑仑）进行长期治疗对大鼠脑离散区域及垂体前叶促肾上腺皮质激素释放因子（CRF）受体调节的影响。如先前报道，我们发现长期抗抑郁药治疗会使大脑皮质中的5-羟色胺2型血清素和β-肾上腺素能受体下调。虽然抗抑郁药治疗后脑干、纹状体、小脑、下丘脑和额叶皮质中的CRF结合有增加趋势，但在丙咪嗪治疗的大鼠中，仅脑干中的变化具有统计学意义。此外，在包括顶叶/颞叶皮质、嗅球、海马体和垂体前叶在内的其他脑区，CRF结合未见显著变化。长期苯二氮䓬类药物治疗后，额叶皮质和海马体中的CRF受体结合显著降低；虽然在其他脑区CRF受体有降低趋势，而在垂体前叶有增加趋势，但这些变化无统计学意义。
