Clark E A, Ledbetter J A
Immunol Today. 1989 Jul;10(7):225-8. doi: 10.1016/0167-5699(89)90257-0.
During 1987, striking advances were made in defining the receptors and ligands for cell-to-cell adhesion interactions involving leukocytes. In 1988, two major leukocyte differentiation antigens, CD10 (cALLA) and CD45 (LCA, T200), were shown to be enzymes while two other markers, CD4 and CD8, were found to be associated with an enzyme. In this article, Ed Clark and Jeff Ledbetter discuss recent findings in the emerging area of leukocyte cell surface enzymology with emphasis on CD45, a membrane-associated protein tyrosine phosphatase (PTPase)2,3.
1987年期间，在确定涉及白细胞的细胞间黏附相互作用的受体和配体方面取得了显著进展。1988年，两种主要的白细胞分化抗原，即CD10（普通急性淋巴细胞白血病抗原）和CD45（白细胞共同抗原，T200）被证明是酶，而另外两种标志物CD4和CD8则被发现与一种酶相关。在本文中，埃德·克拉克和杰夫·莱德贝特讨论了白细胞细胞表面酶学这一新兴领域的最新研究成果，重点是CD45，一种膜相关蛋白酪氨酸磷酸酶（PTPase）2,3。
