脉管系统在干细胞微环境中的指导作用。
The Instructive Role of the Vasculature in Stem Cell Niches.
作者信息
Putnam Andrew J
机构信息
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109.
出版信息
Biomater Sci. 2014 Nov;2(11):1562-1573. doi: 10.1039/C4BM00200H.
Abstract
An important hallmark of many adult stem cell niches is their proximity to the vasculature , a feature common to neural stem cells (NSCs), mesenchymal stem cells (MSCs) from bone marrow, adipose, and other tissues, hematopoietic stem cells (HSCs), and many tumor stem cells. This review summarizes key studies supporting the vasculature's instructive role in adult stem cell niches, and the putative underlying molecular mechanisms by which blood vessels in these niches exert control over progenitor cell fates. The importance of the perivascular niche for pathology, notably tumor metastasis and dormancy, is also highlighted. Finally, the implications of the perivascular regulation of stem and progenitor cells on biomaterial design and the impact on future research directions are discussed.
摘要
许多成体干细胞龛的一个重要标志是它们与脉管系统相邻，这是神经干细胞（NSC）、来自骨髓、脂肪及其他组织的间充质干细胞（MSC）、造血干细胞（HSC）以及许多肿瘤干细胞共有的特征。本综述总结了支持脉管系统在成体干细胞龛中起指导作用的关键研究，以及这些龛中的血管控制祖细胞命运的潜在分子机制。还强调了血管周围龛对病理学的重要性，尤其是肿瘤转移和休眠。最后，讨论了干细胞和祖细胞的血管周围调节对生物材料设计的影响以及对未来研究方向的作用。
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