Scodellaro Chiara, Pina Raquel R, Ferreira Frederico Castelo, Sanjuan-Alberte Paola, Fernandes Tiago G
Department of Bioengineering and Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal.
Associate Laboratory i4HB-Institute for Health and Bioeconomy, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal.
Bioengineering (Basel). 2024 Mar 19;11(3):289. doi: 10.3390/bioengineering11030289.
The field of regenerative medicine has recently witnessed groundbreaking advancements that hold immense promise for treating a wide range of diseases and injuries. At the forefront of this revolutionary progress are stem cells. Stem cells typically reside in specialized environments in vivo, known as microenvironments or niches, which play critical roles in regulating stem cell behavior and determining their fate. Therefore, understanding the complex microenvironments that surround stem cells is crucial for advancing treatment options in regenerative medicine and tissue engineering applications. Several research articles have made significant contributions to this field by exploring the interactions between stem cells and their surrounding niches, investigating the influence of biomechanical and biochemical cues, and developing innovative strategies for tissue regeneration. This review highlights the key findings and contributions of these studies, shedding light on the diverse applications that may arise from the understanding of stem cell microenvironments, thus harnessing the power of these microenvironments to transform the landscape of medicine and offer new avenues for regenerative therapies.
再生医学领域最近取得了突破性进展，为治疗多种疾病和损伤带来了巨大希望。处于这一革命性进展前沿的是干细胞。干细胞通常存在于体内的特殊环境中，即微环境或生态位，这些微环境在调节干细胞行为和决定其命运方面发挥着关键作用。因此，了解干细胞周围复杂的微环境对于推进再生医学和组织工程应用中的治疗方案至关重要。几篇研究文章通过探索干细胞与其周围生态位之间的相互作用、研究生物力学和生化信号的影响以及开发组织再生的创新策略，为该领域做出了重大贡献。本综述重点介绍了这些研究的关键发现和贡献，揭示了对干细胞微环境的理解可能产生的各种应用，从而利用这些微环境的力量改变医学格局并为再生疗法提供新途径。
