Seddigh Ruohollah, Keshavarz-Akhlaghi Amir-Abbas, Shariati Behnam
Mental Health Research Center, Faculty of Behavioral Sciences and Mental Health, Tehran Institute of Psychiatry, Iran University of Medical Sciences, Tehran, Iran.
Case Rep Psychiatry. 2014;2014:845145. doi: 10.1155/2014/845145. Epub 2014 Oct 28.
Background. Methamphetamine-induced psychosis (MIP) in Iran has turned into a serious issue in terms of health and treatment, lacking any obvious treatment methods for its resistant cases. Aims of Case Report. In the present study, a number of two cases of treatment of MIP with clozapine, which were resistant to the treatment with other antipsychotics, have been reported. Both cases completely responded to the treatment in only 2 weeks and no signs of psychosis relapse were seen in an 8-9 follow-up. Conclusion. Because of its particular pharmacologic features, clozapine may be effective in treating MIP.
背景。在伊朗，甲基苯丙胺所致精神病（MIP）在健康和治疗方面已成为一个严重问题，其难治性病例缺乏任何明显的治疗方法。病例报告目的。在本研究中，报告了两例使用氯氮平治疗MIP的病例，这两例对其他抗精神病药物治疗耐药。两例均在仅2周内对治疗完全起效，在8至9个月的随访中未出现精神病复发迹象。结论。由于其特殊的药理学特性，氯氮平可能对治疗MIP有效。
