Matsuo T, Uchino K, Toukairin T, Iwamoto M, Tonosaki Y, Akiyama T, Ogawara H, Fukuchi A
Chem Pharm Bull (Tokyo). 1989 Jul;37(7):1849-51. doi: 10.1248/cpb.37.1849.
New 5'-nucleotidase-inhibitory polyphenols named NPF-86IA, NPF-86IB, NPF-86IIA and NPF-86IIB were isolated from the seeds of Areca catechu L. The ability of the inhibitors to precipitate gelatin was investigated by microturbidimetry. These inhibitors produced weak turbidity. As 5'-nucleotidase is a kind of phosphatase, we examined the effects of these inhibitors on alkaline and acidic phosphatases. While they showed moderate inhibitory effects on the activity of acidic phosphatases, they did not have any significant effect on the activity of alkaline phosphatase. Therefore, they showed a higher inhibitory effect on the 5'-nucleotidase than the other phosphatases, Murine macrophages were directly stimulated by the 5'-nucleotidase inhibitors.
从槟榔种子中分离出了名为NPF-86IA、NPF-86IB、NPF-86IIA和NPF-86IIB的新型5'-核苷酸酶抑制性多酚。通过微量比浊法研究了这些抑制剂沉淀明胶的能力。这些抑制剂产生微弱的浊度。由于5'-核苷酸酶是一种磷酸酶，我们研究了这些抑制剂对碱性磷酸酶和酸性磷酸酶的影响。虽然它们对酸性磷酸酶的活性表现出中等程度的抑制作用，但对碱性磷酸酶的活性没有任何显著影响。因此，它们对5'-核苷酸酶的抑制作用比对其他磷酸酶的抑制作用更强。小鼠巨噬细胞受到5'-核苷酸酶抑制剂的直接刺激。
