Moshirfar Majid, Somani Shaan N, Shmunes Kathryn M, Espandar Ladan, Gokhale Nikhil S, Ronquillo Yasmyne C, Hoopes Phillip C
Hoopes Vision Research Center, Draper, UT, USA.
John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT, USA.
Ophthalmol Ther. 2020 Jun;9(2):265-278. doi: 10.1007/s40123-020-00243-z. Epub 2020 Mar 10.
Microsporidia are a rare and commonly misdiagnosed cause of corneal infection, accounting for approximately 0.4% of cases of microbial keratitis in some populations. Ocular microsporidiosis most often presents as either microsporidial keratoconjunctivitis (MKC) or microsporidial stromal keratitis (MSK). Though these two clinical entities exhibit similar symptomology, they are distinguished from one another by the time course for disease progression, findings on slit-lamp examination, and response to medical therapy. This review summarizes the current literature on the etiology and clinical presentation of microsporidial infections of the cornea and highlights ongoing developments in available diagnostic modalities and treatment regimens.
微孢子虫是角膜感染的一种罕见且常被误诊的病因,在某些人群中约占微生物性角膜炎病例的0.4%。眼部微孢子虫病最常表现为微孢子虫性角膜结膜炎(MKC)或微孢子虫性基质性角膜炎(MSK)。尽管这两种临床病症表现出相似的症状,但它们可通过疾病进展的时间进程、裂隙灯检查结果以及对药物治疗的反应相互区分。本综述总结了关于角膜微孢子虫感染的病因和临床表现的当前文献,并强调了现有诊断方法和治疗方案的持续进展。