Laguna Juan Carlos, Alegret Marta, Roglans Núria
Unit of Pharmacology, Department of Pharmacology and Therapeutic Chemistry, School of Pharmacy, University of Barcelona, Avda. Joan XXIII s.n., 08028 Barcelona, Spain.
Nutrients. 2014 Dec 22;6(12):5933-54. doi: 10.3390/nu6125933.
Sugar intake has dramatically increased during the last few decades. Specifically, there has been a clear trend towards higher consumption of fructose and high fructose corn syrup, which are the most common added sugars in processed food, soft drinks and other sweetened beverages. Although still controversial, this rising trend in simple sugar consumption has been positively associated with weight gain and obesity, insulin resistance and type 2 diabetes mellitus and non-alcoholic fatty liver disease. Interestingly, all of these metabolic alterations have also been related to the development of hepatocellular carcinoma. The purpose of this review is to discuss the evidence coming from epidemiological studies and data from animal models relating the consumption of simple sugars, and specifically fructose, with an increased risk of hepatocellular carcinoma and to gain insight into the putative molecular mechanisms involved.
在过去几十年间，糖的摄入量急剧增加。具体而言，果糖和高果糖玉米糖浆的消费量呈明显上升趋势，它们是加工食品、软饮料及其他甜味饮料中最常见的添加糖。尽管仍存在争议，但单糖消费的这种上升趋势已与体重增加和肥胖、胰岛素抵抗、2型糖尿病以及非酒精性脂肪性肝病呈正相关。有趣的是，所有这些代谢改变也都与肝细胞癌的发生有关。本综述的目的是讨论来自流行病学研究的证据以及动物模型数据，这些证据和数据涉及单糖尤其是果糖的消费与肝细胞癌风险增加之间的关系，并深入了解其中可能涉及的分子机制。
