Wulfrank D A, Schelstraete K H, Small F, Fallais C J
Department of Radiotherapy and Nuclear Medicine, University Hospital Ghent, Belgium.
Clin Nucl Med. 1989 Aug;14(8):588-93. doi: 10.1097/00003072-198908000-00007.
Sixty patients with a variety of malignant tumors were examined with Tc-99m(V) dimercaptosuccinic acid (DMSA) prepared by modification of a commercially available DMSA kit. Significant uptake of Tc-99m(V)-DMSA was observed in a number of tumors, offering additional clinically useful information. In the majority of cases in this study, however, the benefit of the Tc-99m(V)-DMSA image was limited because of low sensitivity. The most striking observation was the similarity between the tumor concentration of Tc-99m(V)-DMSA and the Tc-99m-MDP uptake in the tumor on the regular bone image. Therefore, patients with Tc-99m-MDP uptake in nonosseous tumor sites on the bone scan may be suitable candidates for tumor imaging with Tc-99m(V)-DMSA.
对60例患有各种恶性肿瘤的患者，使用通过改良市售二巯基丁二酸（DMSA）试剂盒制备的锝-99m（V）二巯基丁二酸（DMSA）进行检查。在一些肿瘤中观察到锝-99m（V）-DMSA有明显摄取，提供了额外的临床有用信息。然而，在本研究的大多数病例中，由于敏感性低，锝-99m（V）-DMSA图像的益处有限。最显著的观察结果是锝-99m（V）-DMSA的肿瘤浓度与常规骨显像中肿瘤的锝-99m-亚甲基二膦酸盐（MDP）摄取之间的相似性。因此，在骨扫描中非骨肿瘤部位有锝-99m-MDP摄取的患者可能是使用锝-99m（V）-DMSA进行肿瘤显像的合适候选者。
