Kao C H, Wang S J, Wey S P, Shen L H, Ting G, Yeh S H
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan, Republic of China.
Eur J Nucl Med. 1992;19(10):890-3. doi: 10.1007/BF00168166.
Fifty patients (43 male, 7 female, age 31-77 years) with single solid masses in their lungs based on the findings of a chest X-radiograph [40 malignancies: 5 small cell carcinoma (Ca), 17 epidermoid Ca, 12 adeno Ca, 6 undifferentiated large cell Ca] and 10 benign lesions underwent technetium-99m (V) dimercaptosuccinic acid [99m-(V)DMSA] scans to evaluate the usefulness of 99mTc-(V)DMSA in the detection of lung Ca with different cell types and benign lesions. Only 43% (17/40) of the malignancies in the lungs were detected by 99mTc-(V)DMSA, including 29% (5/17) epidermoid Ca, 50% (6/12) adeno Ca and 17% (1/6) undifferentiated large cell Ca of the lungs. However, all 5 cases of small cell Ca and 11 cases combined with bone metastasis were revealed by 99mTc-(V)DMSA. In addition, 3 of the 10 benign lesions (2 organizing pneumonias, 1 benign tumor) presented with an uptake of 99mTc-(V)DMSA. The diagnostic sensitivity, specificity and accuracy were 43%, 70% and 48%, respectively, in differentiating malignant from benign lesions for the single solid mass in the lungs. In conclusion, 99mTc-(V)DMSA is of little or no use in the differentiation of lung Ca from single solid masses in the lungs.
根据胸部X光片检查结果，50例肺部有单个实性肿块的患者（43例男性，7例女性，年龄31 - 77岁）[40例恶性肿瘤：5例小细胞癌（Ca），17例鳞状上皮细胞癌，12例腺癌，6例未分化大细胞癌]和10例良性病变患者接受了锝-99m（V）二巯基丁二酸[99mTc -（V）DMSA]扫描，以评估99mTc -（V）DMSA在检测不同细胞类型的肺癌及良性病变中的作用。99mTc -（V）DMSA仅检测出43%（17/40）的肺部恶性肿瘤，其中包括29%（5/17）的鳞状上皮细胞癌、50%（6/12）的腺癌和17%（1/6）的肺部未分化大细胞癌。然而，99mTc -（V）DMSA显示出所有5例小细胞癌以及11例合并骨转移的病例。此外，10例良性病变中有3例（2例机化性肺炎，1例良性肿瘤）表现为99mTc -（V）DMSA摄取。在区分肺部单个实性肿块的恶性与良性病变时，诊断敏感性､特异性和准确性分别为43%､70%和48%。总之，99mTc -（V）DMSA在区分肺部单个实性肿块的肺癌方面作用很小或几乎没有作用。
