State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
Department of Pediatric Respiratory Medicine, First Hospital of Jilin University, Jilin Province 130021, PR China.
Colloids Surf B Biointerfaces. 2015 Feb 1;126:367-73. doi: 10.1016/j.colsurfb.2014.11.046. Epub 2014 Dec 8.
Biomimetic glycopolymers poly(gluconamidoethylmethacrylate)-b-poly(ɛ-caprolactone)-b-poly(gluconamidoethylmethacrylate) with degradable disulfide groups in the backbone (PGAMA-PCL-SS-PCL-PGAMA) were synthesized by the combination of ring opening polymerization (ROP) and atom transfer radical polymerization (ATRP). The internal disulfide bonds were cleaved by reduction with dl-dithiothreitol to yield the corresponding thiol terminated glycopolymers. The thiol terminated glycopolymers were effectively anchored on the surface of gold nanoparticles to prepare the biomimetic glycopolymers modified gold nanoparticles (Gly@Au NPs). Moreover, the properties of the Gly@Au NPs in aqueous solution were investigated. Transmission electron microscopy (TEM) analysis revealed that the self-assembly morphology of the Gly@Au NPs can be fine-tuned, from irregular clusters to spherical aggregates, by changing the weight fraction of the hydrophobic PCL block. Furthermore, the Gly@Au NPs had specific recognition with Concanavalin A (Con A).
具有可降解二硫键的仿生糖基聚合物聚（葡糖酰胺乙基甲基丙烯酸酯）-b-聚（ε-己内酯）-b-聚（葡糖酰胺乙基甲基丙烯酸酯）（PGAMA-PCL-SS-PCL-PGAMA）通过开环聚合（ROP）和原子转移自由基聚合（ATRP）的结合合成。内部二硫键通过 dl-二硫苏糖醇还原裂解，生成相应的巯基封端糖聚合物。巯基封端糖聚合物有效地锚定在金纳米粒子表面，制备仿生糖聚合物修饰的金纳米粒子（Gly@Au NPs）。此外，还研究了 Gly@Au NPs 在水溶液中的性质。透射电子显微镜（TEM）分析表明，通过改变疏水性 PCL 嵌段的重量分数，可以精细调节 Gly@Au NPs 的自组装形态，从不规则的聚集体到球形聚集体。此外，Gly@Au NPs 与伴刀豆球蛋白 A（Con A）具有特异性识别。
