MOE Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
Macromol Biosci. 2013 Aug;13(8):1084-91. doi: 10.1002/mabi.201300052. Epub 2013 May 22.
Poly(D,L-lactide)-SS-poly(2-methacryloyloxyethyl phosphorylcholine) block copolymers conjugated with cholesterol are synthesized by ROP and ATRP using a novel kind of double-dead initiator. This facile strategy not only can endue block copolymers with disulfide bonds, but can also overcome the disadvantages inherent in the synthesis procedure for the copolymers. The resultant biomimetic copolymers can self-assemble into near-monodisperse micelles. Subsequently, they are used as a carrier to encapsulate a hydrophobic dye, and the release can be triggered by a redox reagent, dithiothreitol. MTT study shows that the as-prepared micelles has good biocompatibility to both normal and cancer cells. These properties indicate that these micelles may be used as promising drug delivery vehicles.
聚（D，L-丙交酯）-SS-聚（2-甲基丙烯酰氧乙基磷酰胆碱）嵌段共聚物通过 ROP 和 ATRP 使用一种新型双休眠引发剂进行合成。这种简便的策略不仅可以赋予嵌段共聚物二硫键，还可以克服共聚物合成过程中固有的缺点。所得的仿生嵌段共聚物可以自组装成近单分散的胶束。随后，它们被用作载体来包封疏水性染料，并且可以通过氧化还原试剂二硫苏糖醇触发释放。MTT 研究表明，所制备的胶束对正常细胞和癌细胞均具有良好的生物相容性。这些性质表明这些胶束可用作有前途的药物输送载体。
