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本文引用的文献

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A selective review of structural connectivity abnormalities of schizophrenic patients at different stages of the disease.对精神分裂症患者疾病不同阶段结构连接异常的选择性综述。
Schizophr Res. 2015 Jan;161(1):19-28. doi: 10.1016/j.schres.2014.05.020. Epub 2014 Jun 2.
2
fMRI evidence for abnormal resting-state functional connectivity in euthymic bipolar patients.缓解期双相情感障碍患者静息态功能连接异常的功能磁共振成像证据
J Affect Disord. 2014 Aug;165:182-9. doi: 10.1016/j.jad.2014.04.054. Epub 2014 May 5.
3
Altered global brain signal in schizophrenia.精神分裂症患者大脑整体信号改变。
Proc Natl Acad Sci U S A. 2014 May 20;111(20):7438-43. doi: 10.1073/pnas.1405289111. Epub 2014 May 5.
4
A critical appraisal of neuroimaging studies of bipolar disorder: toward a new conceptualization of underlying neural circuitry and a road map for future research.双相障碍神经影像学研究的批判性评价：对潜在神经回路的新概念化及未来研究的路线图。
Am J Psychiatry. 2014 Aug;171(8):829-43. doi: 10.1176/appi.ajp.2014.13081008.
5
Hippocampal volume is reduced in schizophrenia and schizoaffective disorder but not in psychotic bipolar I disorder demonstrated by both manual tracing and automated parcellation (FreeSurfer).通过手动追踪和自动分割（FreeSurfer）显示，精神分裂症和分裂情感性障碍患者的海马体积减小，但双相I型精神障碍伴精神病性症状患者的海马体积未减小。
Schizophr Bull. 2015 Jan;41(1):233-49. doi: 10.1093/schbul/sbu009. Epub 2014 Feb 20.
6
A multicenter tractography study of deep white matter tracts in bipolar I disorder: psychotic features and interhemispheric disconnectivity.一项关于双相 I 障碍深部白质束的多中心轨迹研究：精神病特征和半球间失连接。
JAMA Psychiatry. 2014 Apr;71(4):388-96. doi: 10.1001/jamapsychiatry.2013.4513.
7
Gray matter volume as an intermediate phenotype for psychosis: Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP).灰质体积作为精神病的中间表型：双相-精神分裂症网络中间表型（B-SNIP）。
Am J Psychiatry. 2013 Nov;170(11):1285-96. doi: 10.1176/appi.ajp.2013.13010126.
8
Can structural MRI aid in clinical classification? A machine learning study in two independent samples of patients with schizophrenia, bipolar disorder and healthy subjects.结构磁共振成像能否有助于临床分类？一项针对精神分裂症、双相情感障碍患者及健康受试者的两个独立样本的机器学习研究。
Neuroimage. 2014 Jan 1;84:299-306. doi: 10.1016/j.neuroimage.2013.08.053. Epub 2013 Sep 1.
9
Diffusion tensor imaging white matter endophenotypes in patients with schizophrenia or psychotic bipolar disorder and their relatives.精神分裂症或有精神病性症状的双相障碍患者及其亲属的弥散张量成像白质内表型。
Am J Psychiatry. 2013 Aug;170(8):886-98. doi: 10.1176/appi.ajp.2013.12111448.
10
Clinical staging in psychiatry: a cross-cutting model of diagnosis with heuristic and practical value.精神病学的临床分期：具有启发性和实用性的诊断交叉模型。
Br J Psychiatry. 2013 Apr;202(4):243-5. doi: 10.1192/bjp.bp.112.110858.

通过神经影像学观察克氏二分法。

The Kraepelinian dichotomy viewed by neuroimaging.

作者信息

d'Albis Marc-Antoine, Houenou Josselin

出版信息

Schizophr Bull. 2015 Mar;41(2):330-5. doi: 10.1093/schbul/sbu174. Epub 2014 Dec 22.

DOI:10.1093/schbul/sbu174
PMID:25533269
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4332955/
Abstract

The Kraepelinian dichotomy between schizophrenia (SZ) and bipolar disorder (BD) is being challenged by recent epidemiological and biological studies. We performed a comparative review of neuroimaging features in both conditions at several scales: whole-brain and regional volumes, brain activity, connectivity, and networks. Structural volumetric neuroimaging studies suggest a common pattern of volume decreases, but networks studies reveal a clearer distinction between BD and SZ with an altered connectivity generalized to all brain networks in SZ and restricted to limbic, paralimbic, and interhemispheric networks in BD.

摘要

精神分裂症（SZ）和双相情感障碍（BD）之间的克雷佩林二分法正受到近期流行病学和生物学研究的挑战。我们在几个尺度上对这两种疾病的神经影像学特征进行了比较性综述：全脑和区域体积、脑活动、连通性及网络。结构性体积神经影像学研究表明存在体积减小的共同模式，但网络研究揭示了BD和SZ之间更明显的区别，即SZ中所有脑网络的连通性改变，而BD中连通性改变仅限于边缘系统、边缘旁系统和半球间网络。