Szabo-Reed Amanda N, Breslin Florence J, Lynch Anthony M, Patrician Trisha M, Martin Laura E, Lepping Rebecca J, Powell Joshua N, Yeh Hung-Wen Henry, Befort Christie A, Sullivan Debra, Gibson Cheryl, Washburn Richard, Donnelly Joseph E, Savage Cary R
Department of Internal Medicine, University of Kansas Medical Center, United States.
Center for Health Behavior Neuroscience, University of Kansas Medical Center, United States.
Contemp Clin Trials. 2015 Jan;40:218-31. doi: 10.1016/j.cct.2014.12.008. Epub 2014 Dec 19.
Obesity rates are associated with public health consequences and rising health care costs. Weight loss interventions, while effective, do not work for everyone, and weight regain is a significant problem. Eating behavior is influenced by a convergence of processes in the brain, including homeostatic factors and motivational processing that are important contributors to overeating. Initial neuroimaging studies have identified brain regions that respond differently to visual food cues in obese and healthy weight individuals that are positively correlated with reports of hunger in obese participants. While these findings provide mechanisms of overeating, many important questions remain. It is not known whether brain activation patterns change after weight loss, or if they change differentially based on amount of weight lost. Also, little is understood regarding biological processes that contribute to long-term weight maintenance. This study will use neuroimaging in participants while viewing food and non-food images. Functional Magnetic Resonance Imaging will take place before and after completion of a twelve-week weight loss intervention. Obese participants will be followed though a 6-month maintenance period. The study will address three aims: 1. Characterize brain activation underlying food motivation and impulsive behaviors in obese individuals. 2. Identify brain activation changes and predictors of weight loss. 3. Identify brain activation predictors of weight loss maintenance. Findings from this study will have implications for understanding mechanisms of obesity, weight loss, and weight maintenance. Results will be significant to public health and could lead to a better understanding of how differences in brain activation relate to obesity.
肥胖率与公共卫生后果及不断上升的医疗保健成本相关。减肥干预措施虽然有效，但并非对所有人都起作用，而且体重反弹是一个重大问题。饮食行为受到大脑中多种过程的综合影响，包括稳态因素和动机处理，这些都是导致暴饮暴食的重要因素。最初的神经影像学研究已经确定了肥胖个体和健康体重个体中对视觉食物线索有不同反应的脑区，这些脑区与肥胖参与者的饥饿报告呈正相关。虽然这些发现提供了暴饮暴食的机制，但许多重要问题仍然存在。目前尚不清楚减肥后大脑激活模式是否会改变，或者它们是否会根据体重减轻的量而有不同的变化。此外，对于有助于长期维持体重的生物学过程了解甚少。本研究将在参与者观看食物和非食物图像时使用神经影像学。功能磁共振成像将在为期12周的减肥干预前后进行。肥胖参与者将被跟踪观察6个月的维持期。该研究将实现三个目标：1. 描述肥胖个体中食物动机和冲动行为背后的大脑激活情况。2. 确定大脑激活变化和体重减轻的预测因素。3. 确定体重减轻维持的大脑激活预测因素。这项研究的结果将有助于理解肥胖、减肥和体重维持的机制。结果对公共卫生具有重要意义，并可能有助于更好地理解大脑激活差异与肥胖之间的关系。
