Grzegorzewska Alicja E, Ostromecki Grzegorz, Mostowska Adrianna, Sowińska Anna, Jagodziński Paweł P
Pol Arch Med Wewn. 2015;125(1-2):8-17. doi: 10.20452/pamw.2636. Epub 2015 Dec 23.
There are scarce data on the associations between vitamin D-binding protein gene (GC) polymorphisms and manifestations of chronic kidney disease.
We evaluated the frequency distribution of GC polymorphic variants in hemodialysis (HD) patients and healthy subjects as well as the differences in the prevalence of coronary artery disease (CAD) and myocardial infarction (MI) and selected clinical and laboratory indices of secondary hyperparathyroidism in HD patients (women and men) with different GC polymorphic variants.
HD patients (n = 1056; 625 men) and healthy controls (n = 313; 150 men) were enrolled into the study. The tested GC polymorphisms included rs2298849, rs7041, and rs1155563. We analyzed clinical data (prevalence of CAD and MI; treatment with parathyroidectomy or cinacalcet) and laboratory results (serum calcium, phosphorus, alkaline phosphatase, parathyroid hormone, and 25-hydroxy vitamin D [25(OH)D] in relation to the gene polymorphisms.
There were no differences between the study groups themselves and between the study groups and controls in terms of the frequency distribution of GC polymorphisms (Ptrend <0.05). Lower plasma 25(OH)D levels were shown in subjects with the rs7041 TT genotype compared with those with the GG genotype (12.7, 5.7-20.9 ng/ml vs. 15.9, 8.0-50.0 ng/ml, P = 0.02). Women with the rs7041 TT genotype compared with those with the GG genotype showed higher serum phosphorus levels (5.58, 3.40-8.97 mg/dl vs. 5.03, 1.75-9.33 mg/dl, P = 0.007).
HD patients do not differ in the distribution of GC polymorphisms rs2298849, rs7041, and rs1155563 from healthy subjects. In HD patients, the GC polymorphism is associated with plasma 25(OH)D levels. Sex-related factors may be important in the expression of associations between GC polymorphic variants and mineral disorders.
关于维生素D结合蛋白基因（GC）多态性与慢性肾脏病表现之间关联的数据较少。
我们评估了血液透析（HD）患者和健康受试者中GC多态性变体的频率分布，以及不同GC多态性变体的HD患者（男性和女性）中冠状动脉疾病（CAD）和心肌梗死（MI）的患病率差异，以及继发性甲状旁腺功能亢进的选定临床和实验室指标。
HD患者（n = 1056；625名男性）和健康对照者（n = 313；150名男性）纳入研究。检测的GC多态性包括rs2298849、rs7041和rs1155563。我们分析了临床数据（CAD和MI的患病率；甲状旁腺切除术或西那卡塞治疗）和实验室结果（血清钙、磷、碱性磷酸酶、甲状旁腺激素和25-羟基维生素D [25(OH)D]与基因多态性的关系）。
研究组之间以及研究组与对照组之间在GC多态性的频率分布方面没有差异（Ptrend <0.05）。与GG基因型受试者相比，rs7041 TT基因型受试者的血浆25(OH)D水平较低（12.7，5.7 - 20.9 ng/ml对15.9，8.0 - 50.0 ng/ml，P = 0.02）。与GG基因型女性相比，rs7041 TT基因型女性的血清磷水平较高（5.58，3.40 - 8.97 mg/dl对5.03，1.75 - 9.33 mg/dl，P = 0.007）。
HD患者在rs2298849、rs7041和rs1155563的GC多态性分布上与健康受试者没有差异。在HD患者中，GC多态性与血浆25(OH)D水平相关。性别相关因素可能在GC多态性变体与矿物质紊乱之间关联的表达中起重要作用。
