伊朗多囊卵巢综合征女性中rs7041基因多态性与不孕及复发性流产的关联
The association of rs7041 polymorphism with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome.
作者信息
Hamidi Hediyeh, Kheirollahi Asma, Vatannejad Akram
机构信息
Department of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
出版信息
BMC Res Notes. 2025 May 31;18(1):242. doi: 10.1186/s13104-025-07312-1.
OBJECTIVE
This study aimed to examine the association of rs7041 polymorphism with PCOS, as well as infertility and recurrent pregnancy loss (RPL) in PCOS patients.
RESULTS
Genotype analysis showed that the GT genotype and the T allele of the rs7041 polymorphism were associated with increased odds of PCOS. (OR: 2.8 95% CI [1.48-5.33], p = 0.002, and OR: 2.27 95% CI [1.2-4.28], p = 0.01, respectively). Furthermore, the GT genotype and T allele of the rs7041 polymorphism were associated with increased odds of infertility in women with PCOS. (OR: 40.55 95% CI [5.34-307.7], p < 0.0001, and OR: 30.667 95% CI [4.05-232.19], p = 0.001, respectively). Conversely, no significant association was observed between genotypes and RPL in women with PCOS. Luteinizing hormone (LH) levels were significantly higher in individuals with the T allele compared to those with the G allele.
目的
本研究旨在探讨rs7041多态性与多囊卵巢综合征（PCOS）的关联，以及PCOS患者的不孕和复发性流产（RPL）情况。
结果
基因型分析显示，rs7041多态性的GT基因型和T等位基因与PCOS的患病几率增加相关。（比值比：2.8，95%置信区间[1.48 - 5.33]，p = 0.002；以及比值比：2.27，95%置信区间[1.2 - 4.28]，p = 0.01）。此外，rs7041多态性的GT基因型和T等位基因与PCOS女性的不孕几率增加相关。（比值比：40.55，95%置信区间[5.34 - 307.7]，p < 0.0001；以及比值比：30.667，95%置信区间[4.05 - 232.19]，p = 0.001）。相反，未观察到PCOS女性的基因型与RPL之间存在显著关联。与携带G等位基因的个体相比，携带T等位基因的个体促黄体生成素（LH）水平显著更高。
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