Stock Nathalie
Service d'anatomie et cytologie pathologiques, pôle cellules et tissus, CHU Pontchaillou, 2, rue Henri-le-Guilloux, 35033 Rennes cedex 9, France.
Ann Pathol. 2015 Jan;35(1):41-53. doi: 10.1016/j.annpat.2014.12.001. Epub 2014 Dec 20.
Adipocytic tumors are the most common mesenchymal neoplasms, liposarcoma accounting for approximately 20% of soft tissue sarcomas. The differential diagnosis between benign and malignant tumors is often problematic and represents a significant proportion of consultation cases. The goal of this article is to review liposarcoma subtypes, the main benign adipocytic neoplasms: lipoblastoma, hibernoma, spindle/pleomorphic cell lipoma, chondroid lipoma, as well as non adipocytic neoplasms with a lipomatous component such as lipomatous solitary fibrous tumor, emphasizing on practical differential diagnosis issues, and immunohistochemical and molecular tools allowing their resolution.
脂肪细胞肿瘤是最常见的间叶组织肿瘤,脂肪肉瘤约占软组织肉瘤的20%。良性和恶性肿瘤之间的鉴别诊断常常存在问题,并且在会诊病例中占相当大的比例。本文的目的是回顾脂肪肉瘤的亚型、主要的良性脂肪细胞肿瘤:脂肪母细胞瘤、冬眠瘤、梭形/多形性细胞脂肪瘤、软骨样脂肪瘤,以及具有脂肪成分的非脂肪细胞肿瘤,如脂肪瘤样孤立性纤维性肿瘤,重点关注实际的鉴别诊断问题,以及有助于解决这些问题的免疫组织化学和分子检测方法。