Kobashigawa J A, Johnson M, Rogers J, Vega J D, Colvin-Adams M, Edwards L, Meyer D, Luu M, Reinsmoen N, Dipchand A I, Feldman D, Kormos R, Mancini D, Webber S
Am J Transplant. 2015 Jan;15(1):55-63. doi: 10.1111/ajt.13033.
Since the latest revision in US heart allocation policy (2006), the landscape and volume of transplant waitlists have changed considerably. Advances in mechanical circulatory support (MCS) prolong survival, but Status 1A mortality remains high. Several patient subgroups may be disadvantaged by current listing criteria and geographical disparity remains in waitlist time. This forum on US heart allocation policy was organized to discuss these issues and highlight concepts for consideration in the policy development process. A 25-question survey on heart allocation policy was conducted. Among attendees/respondents were 84 participants with clinical/published experience in heart transplant representing 51 US transplant centers, and OPTN/UNOS and SRTR representatives. The survey results and forum discussions demonstrated very strong interest in change to a further-tiered system, accounting for disadvantaged subgroups and lowering use of exceptions. However, a heart allocation score is not yet viable due to the long-term viability of variables (used in the score) in an ever-developing field. There is strong interest in more refined prioritization of patients with MCS complications, highly sensitized patients and those with severe arrhythmias or restrictive physiology. There is also strong interest in distribution by geographic boundaries modified according to population. Differences of opinion exist between small and large centers.
自美国心脏分配政策的最新修订(2006年)以来,移植等待名单的格局和规模发生了很大变化。机械循环支持(MCS)的进展延长了生存期,但1A类状态的死亡率仍然很高。几个患者亚组可能因当前的列入标准而处于不利地位,等待名单时间的地理差异仍然存在。本次关于美国心脏分配政策的论坛旨在讨论这些问题,并强调在政策制定过程中需要考虑的概念。针对心脏分配政策进行了一项包含25个问题的调查。参会者/受访者中有84名在心脏移植方面有临床/发表经验的参与者,代表了51个美国移植中心,以及器官获取与移植网络(OPTN)/美国器官共享联合网络(UNOS)和科学注册及移植受者数据系统(SRTR)的代表。调查结果和论坛讨论表明,大家对转向进一步分层的系统、考虑处于不利地位的亚组以及减少例外情况的使用有着非常浓厚的兴趣。然而,由于在这个不断发展的领域中,(用于评分的)变量的长期可行性,心脏分配评分目前还不可行。大家对更精细地对患有MCS并发症的患者、高敏患者以及患有严重心律失常或限制性生理状况的患者进行优先排序有着浓厚兴趣。对于根据人口情况修改地理边界进行分配也有浓厚兴趣。大小中心之间存在意见分歧。