细菌、内质网和未折叠蛋白反应：是敌是友？
Bacteria, the endoplasmic reticulum and the unfolded protein response: friends or foes?
机构信息
Paul G. Allen School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, Washington 99164, USA.
Department of Medical Microbiology and Immunology, University of California Davis School of Medicine, Davis, California 95616, USA.
出版信息
Nat Rev Microbiol. 2015 Feb;13(2):71-82. doi: 10.1038/nrmicro3393. Epub 2014 Dec 15.
Abstract
The unfolded protein response (UPR) is a cytoprotective response that is aimed at restoring cellular homeostasis following physiological stress exerted on the endoplasmic reticulum (ER), which also invokes innate immune signalling in response to invading microorganisms. Although it has been known for some time that the UPR is modulated by various viruses, recent evidence indicates that it also has multiple roles during bacterial infections. In this Review, we describe how bacteria interact with the ER, including how bacteria induce the UPR, how subversion of the UPR promotes bacterial proliferation and how the UPR contributes to innate immune responses against invading bacteria.
摘要
未折叠蛋白反应（UPR）是一种细胞保护反应，旨在恢复内质网（ER）受到生理压力后的细胞内稳态，同时也会对入侵的微生物产生固有免疫信号。虽然人们已经知道一段时间，UPR 受到各种病毒的调节，但最近的证据表明，它在细菌感染中也有多种作用。在这篇综述中，我们描述了细菌与 ER 的相互作用方式，包括细菌如何诱导 UPR，UPR 的颠覆如何促进细菌增殖，以及 UPR 如何促进对入侵细菌的固有免疫反应。
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