Wu Evan S, Rothbard Aileen, Holtgrave David R, Blank Michael B
Department of Psychiatry, Center for Mental Health Policy and Services Research, University of Pennsylvania, 3535 Market Street, #3103, Philadelphia, PA, 19104, USA.
Leonard David Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA.
Community Ment Health J. 2016 May;52(4):439-45. doi: 10.1007/s10597-014-9788-6. Epub 2014 Dec 23.
Persons with serious mental illnesses are at increased risk for contracting and transmitting HIV and often have poor adherence to medication regimens. Determining the economic feasibility of different HIV adherence interventions among individuals with HIV and serious mental illness is important for program planners who must make resource allocation decisions. The goal of this study was to provide a methodology to estimate potential cost savings from an HIV medication adherence intervention program for a new study population, using data from prior published studies. The novelty of this approach is the way CD4 count data was used as a biological marker to estimate costs averted by greater adherence to anti-retroviral treatment. Our approach is meant to be used in other adherence intervention studies requiring cost modeling.
患有严重精神疾病的人感染和传播艾滋病毒的风险增加，而且往往对药物治疗方案的依从性较差。对于必须做出资源分配决策的项目规划者来说，确定针对感染艾滋病毒且患有严重精神疾病的个体的不同艾滋病毒依从性干预措施的经济可行性非常重要。本研究的目的是提供一种方法，利用先前发表研究的数据，估计针对新研究人群的艾滋病毒药物依从性干预项目可能节省的成本。这种方法的新颖之处在于，将CD4细胞计数数据用作生物学标志物，以估计通过更好地坚持抗逆转录病毒治疗而避免的成本。我们的方法旨在用于其他需要成本建模的依从性干预研究。
