Wang C, Liu J N, Xu L, Mu Y L, Sun P
Department of Oncology, Yantai Yuhuangding Hospital, Affiliated to Qingdao University, Yantai, Shandong, China.
Eur Rev Med Pharmacol Sci. 2014;18(23):3632-7.
To investigate the impression of glucosylceramide synthase (GCS) in colorectal carcinoma tissues.
Immunohistochemical method was used to detect the expression of GCS in 188 cases of colorectal carcinoma tissues and 80 cases of non-cancerous colorectal tissues. The expression of GCS and the relation with age, gender, tumor location, Tumor stage, differentiation, lymph node metastasis were analyzed. Thus, we further discussed whether to accept neoadjuvant chemotherapy can affect the expression of GCS.
GCS was overexpressed in colorectal carcinoma tissues compared with non-cancerous colorectal tissues; the expression of GCS was associated with lymph node metastasis, but not associated with age, gender, tumor location, differentiation and Tumor stage. What's more, the positive expression rate of GCS in patients who receiving neoadjuvant chemotherapy was higher than that in untreated patients.
GCS was upregulated in colorectal carcinoma tissues. It might not only play an important role in controlling the generation and progression of colorectal carcinoma, but also be a factor of MDR.
研究葡糖神经酰胺合酶（GCS）在结直肠癌组织中的表达情况。
采用免疫组织化学方法检测188例结直肠癌组织和80例结直肠非癌组织中GCS的表达。分析GCS的表达与年龄、性别、肿瘤部位、肿瘤分期、分化程度、淋巴结转移的关系。进而探讨接受新辅助化疗与否是否会影响GCS的表达。
与结直肠非癌组织相比，GCS在结直肠癌组织中高表达；GCS的表达与淋巴结转移有关，但与年龄、性别、肿瘤部位、分化程度及肿瘤分期无关。此外，接受新辅助化疗患者的GCS阳性表达率高于未接受治疗的患者。
GCS在结直肠癌组织中上调。它可能不仅在控制结直肠癌的发生和发展中起重要作用，而且还是多药耐药的一个因素。
