[组胺能性血管性水肿与慢性荨麻疹]

[Histaminergic angioedema and chronic urticaria].

作者信息

Hacard Florence, Nosbaum Audrey, Bensaid Benoit, Nicolas Jean-François, Augey Frédéric, Goujon Catherine, Bérard Frédéric

机构信息

Hospices civils de Lyon, centre hospitalier Lyon-Sud, service d'allergologie et d'immunologie clinique, 69495 Pierre-Bénite, France; Inserm U1111-CIRI/UMS3444/US8, 21, avenue Tony-Garnier, 69007 Lyon, France; Université Claude-Bernard Lyon I, UFR médecine Lyon-Sud Charles-Mérieux, 69921 Oullins cedex, France.

出版信息

Presse Med. 2015 Jan;44(1):37-42. doi: 10.1016/j.lpm.2014.11.001. Epub 2014 Dec 18.

DOI:10.1016/j.lpm.2014.11.001

PMID:25535159

Abstract

Most angioedemas are histaminergic and correspond to deep urticarial swelling. Recurrent histaminergic angioedema led to the diagnosis of chronic urticaria, even when there are no superficial associated hives. Chronic urticaria is a benign disease, and autoimmune in 40 % of cases. The occurrence of angioedema in chronic urticaria is not a sign of severity. The occurrence of angioedema in chronic urticaria is associated with a longer duration of urticarial disease. NSAIDs and/or systemic corticotherapy are classic triggers of angioedema in chronic urticaria. In the absence of clinical endpoints, there is no need to make further assessment in chronic urticaria good responders to antihistamines.

摘要

大多数血管性水肿是组胺能性的，与深部荨麻疹肿胀相对应。复发性组胺能性血管性水肿可导致慢性荨麻疹的诊断，即使没有相关的浅表性荨麻疹。慢性荨麻疹是一种良性疾病，40%的病例为自身免疫性。慢性荨麻疹中血管性水肿的出现并非严重程度的标志。慢性荨麻疹中血管性水肿的出现与荨麻疹病程较长有关。非甾体抗炎药和/或全身皮质激素治疗是慢性荨麻疹中血管性水肿的典型触发因素。在没有临床终点的情况下，对于对抗组胺药反应良好的慢性荨麻疹患者无需进行进一步评估。