Scherrer Karin Sofia, Weitz Marcus, Eisenack Johannes, Truffer Béatrice, Konrad Daniel
General Paediatrics, University Children's Hospital, 8032, Zurich, Switzerland,
Eur J Pediatr. 2015 Mar;174(3):399-401. doi: 10.1007/s00431-014-2477-1. Epub 2014 Dec 24.
Iatrogenic Cushing syndrome induced by oral and parenteral corticosteroid administration is a well-known complication, and necessary precautions have to be taken. Cushing syndrome, however, following treatment with glucocorticoid-containing eye drops is a very rare complication. To the best of our knowledge, there have been only four reported cases in the literature. Herein, we present an infant boy who developed Cushing syndrome after receiving dexamethasone-containing eye drops after bilateral cataract extraction to prevent postoperative inflammatory complications. At the age of 5 months, after approx. 3 months of dexamethasone therapy, the patient presented with cushingoid facies, nephrocalcinosis and failure to grow. Iatrogenic Cushing syndrome was diagnosed and dexamethasone-containing eye drops were reduced and eventually stopped. Follow-up examinations revealed catch-up growth.
Ocularly administered corticosteroids may have substantial systemic side effects in infants.
口服和胃肠外给予皮质类固醇激素引起的医源性库欣综合征是一种众所周知的并发症，必须采取必要的预防措施。然而，使用含糖皮质激素的眼药水治疗后发生库欣综合征是一种非常罕见的并发症。据我们所知，文献中仅报道过4例。在此，我们报告一名男婴，其在双侧白内障摘除术后接受含地塞米松的眼药水以预防术后炎症并发症后发生了库欣综合征。5个月大时，在大约3个月的地塞米松治疗后，该患者出现了库欣面容、肾钙质沉着症和生长发育迟缓。诊断为医源性库欣综合征，含地塞米松的眼药水减量并最终停用。随访检查显示出现追赶生长。
眼部给予皮质类固醇激素在婴儿中可能有显著的全身副作用。
