Kanno T, Kurioka N, Kim S, Tamori A, Kim K, Oka H, Kuroki T, Mizoguchi Y, Kobayashi K
Department of Internal Medicine, Tadaoka Municipal Hospital, Japan.
Gastroenterol Jpn. 1989 Oct;24(5):528-34. doi: 10.1007/BF02773880.
Of 34 solitary small hepatocellular carcinomas (HCC) 2 cm in diameter or less, 13 with hyperechoic lesions were observed serially by sonography, and 11 of these were examined histologically. Serial examination showed that hypoechoic areas appeared at the periphery of or within, the hyperechoic tumor, and that these areas expanded more with tumor growth than the hyperechoic areas as if compressing or displacing the existing hyperechoic areas. Histologically, the hyperechoic lesions were composed mostly of well-differentiated cancer cells containing fat droplets, whereas the hypoechoic lesions were composed of cancer cells without fat droplets. In the two tumors that were formed almost completely of cancer cells showing fatty metamorphosis, cancer cells without fat droplets proliferated mainly in the periphery of the tumor. These findings suggest that, in hyperechoic HCC, cancer cells with fat droplets appear in the early stage of HCC, and probably change into concer cells without fat droplets by the time that a certain tumor size is reached, with gradual displacement by the latter type of cell during tumor growth.
在34个直径小于或等于2cm的孤立性小肝细胞癌（HCC）中，对13个具有高回声病变的肿瘤进行了超声连续观察，其中11个进行了组织学检查。连续检查显示，低回声区出现在高回声肿瘤的周边或内部，并且随着肿瘤生长，这些低回声区比高回声区扩展得更多，就好像在挤压或取代现有的高回声区。组织学上，高回声病变主要由含有脂肪滴的高分化癌细胞组成，而低回声病变则由不含脂肪滴的癌细胞组成。在几乎完全由表现为脂肪变性的癌细胞形成的两个肿瘤中，不含脂肪滴的癌细胞主要在肿瘤周边增殖。这些发现表明，在高回声型肝癌中，含脂肪滴的癌细胞出现在肝癌的早期，当肿瘤达到一定大小时，可能会转变为不含脂肪滴的癌细胞，在肿瘤生长过程中逐渐被后一种类型的细胞取代。
