1型糖尿病、血糖不稳定及血脂参数的青少年初始晶状体透明度与眼循环之间的关系
Relationship between Initial Lens Transparency and Ocular Circulation in Adolescents with Type-1 Diabetes Mellitus, Unstable Glycaemia and Lipid Parameters.
作者信息
Modrzejewska Monika, Grzesiak Wilhelm, Zaborski Daniel, Wilk Grażyna, Modrzejewska Anna
机构信息
Department of Ophthalmology, Pomeranian Medical University, Szczecin, Poland.
Laboratory of Biostatistics, West Pomeranian University of Technology, Szczecin, Poland.
出版信息
Pol J Radiol. 2014 Dec 18;79:472-8. doi: 10.12659/PJR.890852. eCollection 2014.
BACKGROUND
The aim of this study was to determine the relationships between lens opacity, vascular and lipid factors and retrobulbar blood flow parameters in type-1 diabetic (DM) adolescents.
MATERIAL/METHODS: Glycated haemoglobin (HbA1c), total cholesterol (TCH), high- and low-density cholesterol, triglycerides (TG) and apolipoprotein B (ApoB) were determined in 28 patients with (DM-1) and without (DM-0) lens opacity and 18 controls. In the ophthalmic, central retinal (CRA) and temporal posterior ciliary (TPCA) arteries, the systolic (PSV), end-diastolic and mean blood flow velocities as well as pulsatility and resistance (RI) indices were measured.
RESULTS
Ten (35.71%) diabetic patients exhibited lens opacification. Higher TG and TCH levels in the DM-1 group and HbA1c level in the DM-0 and DM-1 groups were observed (P≤0.05). Diabetic patients had lower PSV and higher RI within CRA and TPCA (P≤0.05). Significant correlations between biochemical and blood flow parameters were found.
CONCLUSIONS
Glycaemic and lipid factors may play a vasoconstrictive role in retrobulbar endotheliopathy.
背景
本研究旨在确定1型糖尿病（DM）青少年晶状体混浊、血管和脂质因素与球后血流参数之间的关系。
材料/方法：对28例有（DM-1）和无（DM-0）晶状体混浊的患者以及18名对照者测定糖化血红蛋白（HbA1c）、总胆固醇（TCH）、高密度和低密度胆固醇、甘油三酯（TG）和载脂蛋白B（ApoB）。在眼动脉、视网膜中央动脉（CRA）和颞侧后睫状动脉（TPCA）中，测量收缩期（PSV）、舒张末期和平均血流速度以及搏动性和阻力（RI）指数。
结果
10例（35.71%）糖尿病患者出现晶状体混浊。观察到DM-1组的TG和TCH水平较高，DM-0组和DM-1组的HbA1c水平较高（P≤0.05）。糖尿病患者CRA和TPCA内的PSV较低，RI较高（P≤0.05）。发现生化参数和血流参数之间存在显著相关性。
结论
血糖和脂质因素可能在球后内皮病变中起血管收缩作用。
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