Sánchez-Franco F, Fernández L, Fernández G, Cacicedo L
Servicio de Endocrinología, Hospital Ramón y Cajal, Madrid, Spain.
Horm Metab Res. 1989 Oct;21(10):550-2. doi: 10.1055/s-2007-1009285.
Thyroid hormone effects on pituitary ACTH have not been well established. Adult male Sprague-Dawley rats were rendered hypo- and hyperthyroid while undergoing treatment with 6-Propylthiouracil (PTU) and L-Thyroxine (T4). At the time of decapitation, plasma values for T4 (micrograms/100 ml) were 3.9 +/- 0.4 in the control, 17.3 +/- 2.2 in the T4 and less than 2 in the PTU treated group; plasma T3 and TSH confirmed hyper- and hypothyroidism in the T4 and PTU treated groups respectively. Plasma immunoassayable ACTH and corticosterone were significantly increased in hyperthyroid and decreased in the PTU treated animals. Pituitaries were removed and incubated in DMEM. After 3 h incubation, ACTH content and secretion to the medium were significantly lower in the PTU group. As expected, pituitary TSH content and secretion were decreased in the T4 treated animals. These data indicate that thyroid hormones influence pituitary-adrenal function by increasing ACTH secretion and consequently corticosterone production.
甲状腺激素对垂体促肾上腺皮质激素（ACTH）的影响尚未完全明确。成年雄性Sprague-Dawley大鼠在接受6-丙基硫氧嘧啶（PTU）和L-甲状腺素（T4）治疗时分别导致甲状腺功能减退和亢进。断头时，对照组血浆T4值（微克/100毫升）为3.9±0.4，T4治疗组为17.3±2.2，PTU治疗组小于2；血浆T3和促甲状腺激素（TSH）分别证实T4治疗组和PTU治疗组存在甲状腺功能亢进和减退。甲状腺功能亢进动物的血浆免疫活性ACTH和皮质酮显著增加，PTU治疗动物则降低。取出垂体并在杜氏改良 Eagle培养基（DMEM）中培养。培养3小时后，PTU组垂体ACTH含量及向培养基中的分泌显著降低。正如预期的那样，T4治疗动物的垂体TSH含量及分泌减少。这些数据表明，甲状腺激素通过增加ACTH分泌进而增加皮质酮生成来影响垂体-肾上腺功能。
